Sex Hormone Binding Globulin (SHBG)

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ABP; TEBG; SBP; Sex steroid-binding protein; Testis-specific androgen-binding protein; Testosterone-estradiol-binding globulin; Testosterone-estrogen-binding globulin

Sex Hormone Binding Globulin (SHBG)

SHBG is a glycoprotein that binds to sex hormones, specifically testosterone and estradiol. Other steroid hormones such as progesterone, cortisol, and other corticosteroids are bound by transcortin. These sex hormones circulate in the bloodstream, bound mostly to SHBG and to some degree bound to serum albumin. Only a small fraction is unbound, or "free," and thus biologically active and able to enter a cell and activate its receptor. The SHBG inhibits the function of these hormones. Thus bioavailability of sex hormones is influenced by the level of SHBG. SHBG is produced by the liver cells and is released into the bloodstream. Other sites that produce SHBG are the brain, uterus, and placenta and vagina. In addition SHBG is produced by the testes; testes-produced SHBG is also called androgen-binding protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA396Hu01 Recombinant Sex Hormone Binding Globulin (SHBG) Positive Control; Immunogen; SDS-PAGE; WB.
RPA396Hu02 Recombinant Sex Hormone Binding Globulin (SHBG) Positive Control; Immunogen; SDS-PAGE; WB.
EPA396Hu61 Eukaryotic Sex Hormone Binding Globulin (SHBG) Positive Control; Immunogen; SDS-PAGE; WB.
EPA396Hu62 Eukaryotic Sex Hormone Binding Globulin (SHBG) Positive Control; Immunogen; SDS-PAGE; WB.
APA396Hu61 Active Sex Hormone Binding Globulin (SHBG) Cell culture; Activity Assays.
APA396Hu62 Active Sex Hormone Binding Globulin (SHBG) Cell culture; Activity Assays.
Antibodies PAA396Hu01 Polyclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC; IP.
MAA396Hu22 Monoclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC; IP.
LAA396Hu71 Biotin-Linked Polyclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC.
LAA396Hu81 FITC-Linked Polyclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC; IF.
PAA396Hu02 Polyclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC; IP.
MAA396Hu21 Monoclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC; IP.
Assay Kits SEA396Hu ELISA Kit for Sex Hormone Binding Globulin (SHBG) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA396Mu01 Recombinant Sex Hormone Binding Globulin (SHBG) Positive Control; Immunogen; SDS-PAGE; WB.
RPA396Mu02 Recombinant Sex Hormone Binding Globulin (SHBG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA396Mu01 Polyclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC; IP.
LAA396Mu71 Biotin-Linked Polyclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC.
PAA396Mu02 Polyclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC; IP.
Assay Kits SEA396Mu ELISA Kit for Sex Hormone Binding Globulin (SHBG) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA396Ra01 Recombinant Sex Hormone Binding Globulin (SHBG) Positive Control; Immunogen; SDS-PAGE; WB.
RPA396Ra02 Recombinant Sex Hormone Binding Globulin (SHBG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA396Ra01 Polyclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC; IP.
LAA396Ra71 Biotin-Linked Polyclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC.
LAA396Ra81 FITC-Linked Polyclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC; IF.
MAA396Ra21 Monoclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC; IP.
PAA396Ra02 Polyclonal Antibody to Sex Hormone Binding Globulin (SHBG) WB; IHC; ICC; IP.
Assay Kits SEA396Ra ELISA Kit for Sex Hormone Binding Globulin (SHBG) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "The human sex hormone-binding globulin gene contains exons for androgen-binding protein and two other testicular messenger RNAs."Mol. Endocrinol. 3:1869-1876(1989) [PubMed] [Europe PMC] [Abstract]
  3. "PCR isolation and cloning of novel splice variant mRNAs from known drug target genes."Genomics 83:566-571(2004) [PubMed] [Europe PMC] [Abstract]
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  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  11. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
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  14. "Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain."EMBO J. 19:504-512(2000) [PubMed] [Europe PMC] [Abstract]
  15. "Steroid ligands bind human sex hormone-binding globulin in specific orientations and produce distinct changes in protein conformation."J. Biol. Chem. 277:32086-32093(2002) [PubMed] [Europe PMC] [Abstract]
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  17. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  18. ErratumNat. Genet. 23:373-373(1999)