Galectin 9 (GAL9)
[Edit]LGALS9; Ecalectin; Lectin,Galactoside-Binding Soluble 9; Tumor antigen HOM-HD-21
-90309.jpg)
Galectin-9 (Gal-9) is a member of animal lectins that have an affinity to beta-galactosides. Gal-9 was first cloned from tumor tissues of Hodgkin’s disease that is frequently characterized by eosinophilia. Galectins exhibit various biological functions, such as cell aggregation and adhesion, proliferation,cell death, modulation of inflammation and metastasis.First, Gal-9/ecalectin was identified as a potent T cellderived eosinophil chemoattractant (ECA).
Gal-9 exhibits ECA activity in vitro and in vivo, activates eosinophils, and influences eosinophil survival. It requires divalent galactoside- binding activity but not its linker peptide to exhibit its functions , and some matrix metalloproteinases are involved in the release.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA309Hu01 | Recombinant Galectin 9 (GAL9) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA309Hu01 | Active Galectin 9 (GAL9) | Cell culture; Activity Assays. | |
| APA309Hu61 | Active Galectin 9 (GAL9) | Cell culture; Activity Assays. | |
| EPA309Hu61 | Eukaryotic Galectin 9 (GAL9) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA309Hu01 | Polyclonal Antibody to Galectin 9 (GAL9) | WB; IHC |
| MAA309Hu22 | Monoclonal Antibody to Galectin 9 (GAL9) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA309Hu | ELISA Kit for Galectin 9 (GAL9) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCA309Hu | CLIA Kit for Galectin 9 (GAL9) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA309Mu01 | Recombinant Galectin 9 (GAL9) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA309Mu02 | Recombinant Galectin 9 (GAL9) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA309Mu01 | Active Galectin 9 (GAL9) | Cell culture; Activity Assays. | |
| APA309Mu02 | Active Galectin 9 (GAL9) | Cell culture; Activity Assays. | |
| Antibodies | PAA309Mu01 | Polyclonal Antibody to Galectin 9 (GAL9) | WB; IHC; ICC; IP. |
| PAA309Mu02 | Polyclonal Antibody to Galectin 9 (GAL9) | WB; IHC; ICC; IP. | |
| LAA309Mu71 | Biotin-Linked Polyclonal Antibody to Galectin 9 (GAL9) | WB; IHC; ICC. | |
| Assay Kits | SEA309Mu | ELISA Kit for Galectin 9 (GAL9) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCA309Mu | CLIA Kit for Galectin 9 (GAL9) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA309Ra01 | Recombinant Galectin 9 (GAL9) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA309Ra02 | Recombinant Galectin 9 (GAL9) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA309Ra01 | Active Galectin 9 (GAL9) | Cell culture; Activity Assays. | |
| Antibodies | PAA309Ra01 | Polyclonal Antibody to Galectin 9 (GAL9) | WB; IHC; ICC; IP. |
| PAA309Ra02 | Polyclonal Antibody to Galectin 9 (GAL9) | WB; IHC; ICC; IP. | |
| LAA309Ra71 | Biotin-Linked Polyclonal Antibody to Galectin 9 (GAL9) | WB; IHC; ICC. | |
| Assay Kits | SEA309Ra | ELISA Kit for Galectin 9 (GAL9) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Canis familiaris; Canine (Dog)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA309Ca01 | Recombinant Galectin 9 (GAL9) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA309Ca01 | Polyclonal Antibody to Galectin 9 (GAL9) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Galectin 9 (GAL9) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Galectin 9 (GAL9) | ELISA Kit Customized Service Offer |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA309Po01 | Recombinant Galectin 9 (GAL9) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA309Po01 | Polyclonal Antibody to Galectin 9 (GAL9) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Galectin 9 (GAL9) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Galectin 9 (GAL9) | ELISA Kit Customized Service Offer |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA309Bo01 | Recombinant Galectin 9 (GAL9) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA309Bo01 | Polyclonal Antibody to Galectin 9 (GAL9) | WB; IHC; ICC; IP. |
| LAA309Bo71 | Biotin-Linked Polyclonal Antibody to Galectin 9 (GAL9) | WB; IHC; ICC. | |
| Assay Kits | n/a | CLIA Kit for Galectin 9 (GAL9) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Galectin 9 (GAL9) | ELISA Kit Customized Service Offer |
- "Molecular definition of a novel human galectin which is immunogenic in patients with Hodgkin's disease."J. Biol. Chem. 272:6416-6422(1997) [PubMed] [Europe PMC] [Abstract]
- "Human ecalectin, a variant of human galectin-9, is a novel eosinophil chemoattractant produced by T lymphocytes."J. Biol. Chem. 273:16976-16984(1998) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity."Nat. Immunol. 6:1245-1252(2005) [PubMed] [Europe PMC] [Abstract]
- "Structural analysis of the human galectin-9 N-terminal carbohydrate recognition domain reveals unexpected properties that differ from the mouse orthologue."J. Mol. Biol. 375:119-135(2008) [PubMed] [Europe PMC] [Abstract]
- "Crystal structure of N-terminal domain of human galectin-9 containing L-acetyllactosamine."Submitted (APR-2008) to the PDB data bank
- "Structural analysis of the recognition mechanism of poly-N-acetyllactosamine by the human galectin-9 N-terminal carbohydrate recognition domain."Glycobiology 19:112-117(2009) [PubMed] [Europe PMC] [Abstract]
- "X-ray structures of human galectin-9 C-terminal domain in complexes with a biantennary oligosaccharide and sialyllactose."J. Biol. Chem. 285:36969-36976(2010) [PubMed] [Europe PMC] [Abstract]