Transforming Growth Factor Beta 2 (TGFb2)

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TGF-B2; TGF-Beta2; G-TSF; LAP; Cetermin; Polyergin; Latency-associated peptide; BSC-1 cell growth inhibitor; Glioblastoma-derived T-cell suppressor factor

Transforming Growth Factor Beta 2 (TGFb2)

TGFB2 is present at elevated levels in the aqueous humor of patients with primary open angle glaucoma (POAG). Studies have shown that TGFB2 influences cultured trabecular meshwork cells.TGFB2 reduced outflow facility when perfused into cultured human anterior segments. Furthermore, TGFB2 affected the extracellular matrix of the trabecular meshwork in a manner that was consistent with the observed reduction in outflow facility. Although the distribution of accumulated fibrillar material was different in these perfused eyes than that in POAG, the difference could have been due to variation in biomechanical environment for trabecular meshwork cells in cultured anterior segments compared with the living eye. elevated TGFB2 levels in the aqueous humor played a role in the pathogenesis of the ocular hypertension in POAG.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA218Hu01 Recombinant Transforming Growth Factor Beta 2 (TGFb2) Positive Control; Immunogen; SDS-PAGE; WB.
APA218Hu01 Active Transforming Growth Factor Beta 2 (TGFb2) Cell culture; Activity Assays.
Antibodies PAA218Hu01 Polyclonal Antibody to Transforming Growth Factor Beta 2 (TGFb2) WB; IHC
MAA218Hu22 Monoclonal Antibody to Transforming Growth Factor Beta 2 (TGFb2) WB; IHC; ICC; IP.
MAA218Hu21 Monoclonal Antibody to Transforming Growth Factor Beta 2 (TGFb2) WB; IHC; ICC; IP.
Assay Kits CEA218Hu ELISA Kit for Transforming Growth Factor Beta 2 (TGFb2) Enzyme-linked immunosorbent assay for Antigen Detection.
SEA218Hu ELISA Kit for Transforming Growth Factor Beta 2 (TGFb2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA218Mu01 Recombinant Transforming Growth Factor Beta 2 (TGFb2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA218Mu02 Recombinant Transforming Growth Factor Beta 2 (TGFb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA218Mu01 Polyclonal Antibody to Transforming Growth Factor Beta 2 (TGFb2) WB; IHC; ICC; IP.
PAA218Mu02 Polyclonal Antibody to Transforming Growth Factor Beta 2 (TGFb2) WB; IHC; ICC; IP.
Assay Kits CEA218Mu ELISA Kit for Transforming Growth Factor Beta 2 (TGFb2) Enzyme-linked immunosorbent assay for Antigen Detection.
SEA218Mu ELISA Kit for Transforming Growth Factor Beta 2 (TGFb2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA218Ra01 Recombinant Transforming Growth Factor Beta 2 (TGFb2) Positive Control; Immunogen; SDS-PAGE; WB.
APA218Ra01 Active Transforming Growth Factor Beta 2 (TGFb2) Cell culture; Activity Assays.
RPA218Ra02 Recombinant Transforming Growth Factor Beta 2 (TGFb2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA218Ra03 Recombinant Transforming Growth Factor Beta 2 (TGFb2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA218Ra04 Recombinant Transforming Growth Factor Beta 2 (TGFb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA218Ra01 Polyclonal Antibody to Transforming Growth Factor Beta 2 (TGFb2) WB; IHC; ICC; IP.
MAA218Ra21 Monoclonal Antibody to Transforming Growth Factor Beta 2 (TGFb2) WB; IHC; ICC; IP.
Assay Kits SEA218Ra ELISA Kit for Transforming Growth Factor Beta 2 (TGFb2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA218Rb01 Recombinant Transforming Growth Factor Beta 2 (TGFb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA218Rb51 Polyclonal Antibody to Transforming Growth Factor Beta 2 (TGFb2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Transforming Growth Factor Beta 2 (TGFb2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transforming Growth Factor Beta 2 (TGFb2) ELISA Kit Customized Service Offer

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA218Si01 Recombinant Transforming Growth Factor Beta 2 (TGFb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA218Si01 Polyclonal Antibody to Transforming Growth Factor Beta 2 (TGFb2) WB; IHC; ICC; IP.
MAA218Si21 Monoclonal Antibody to Transforming Growth Factor Beta 2 (TGFb2) WB; IHC; ICC; IP.
Assay Kits SEA218Si ELISA Kit for Transforming Growth Factor Beta 2 (TGFb2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA218Ca01 Recombinant Transforming Growth Factor Beta 2 (TGFb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA218Ca01 Polyclonal Antibody to Transforming Growth Factor Beta 2 (TGFb2) WB; IHC; ICC; IP.
MAA218Ca21 Monoclonal Antibody to Transforming Growth Factor Beta 2 (TGFb2) WB; IHC; ICC; IP.
Assay Kits SEA218Ca ELISA Kit for Transforming Growth Factor Beta 2 (TGFb2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA218Po01 Recombinant Transforming Growth Factor Beta 2 (TGFb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA218Po01 Polyclonal Antibody to Transforming Growth Factor Beta 2 (TGFb2) WB; IHC; ICC; IP.
Assay Kits SEA218Po ELISA Kit for Transforming Growth Factor Beta 2 (TGFb2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA218Bo01 Recombinant Transforming Growth Factor Beta 2 (TGFb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA218Bo01 Polyclonal Antibody to Transforming Growth Factor Beta 2 (TGFb2) WB; IHC; ICC; IP.
MAA218Bo21 Monoclonal Antibody to Transforming Growth Factor Beta 2 (TGFb2) WB; IHC; ICC; IP.
Assay Kits SEA218Bo ELISA Kit for Transforming Growth Factor Beta 2 (TGFb2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA218Cp01 Recombinant Transforming Growth Factor Beta 2 (TGFb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA218Cp01 Polyclonal Antibody to Transforming Growth Factor Beta 2 (TGFb2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Transforming Growth Factor Beta 2 (TGFb2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transforming Growth Factor Beta 2 (TGFb2) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA218Ga01 Recombinant Transforming Growth Factor Beta 2 (TGFb2) Positive Control; Immunogen; SDS-PAGE; WB.
APA218Ga01 Active Transforming Growth Factor Beta 2 (TGFb2) Cell culture; Activity Assays.
Antibodies PAA218Ga01 Polyclonal Antibody to Transforming Growth Factor Beta 2 (TGFb2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Transforming Growth Factor Beta 2 (TGFb2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transforming Growth Factor Beta 2 (TGFb2) ELISA Kit Customized Service Offer
  1. "Complementary DNA for human glioblastoma-derived T cell suppressor factor, a novel member of the transforming growth factor-beta gene family."EMBO J. 6:3673-3677(1987) [PubMed] [Europe PMC] [Abstract]
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  3. "Structural and sequence analysis of TGF-beta 2 cDNA clones predicts two different precursor proteins produced by alternative mRNA splicing."DNA 7:493-497(1988) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Molecular cloning and structure of the human transforming growth factor-beta 2 gene promoter."Growth Factors 4:247-255(1991) [PubMed] [Europe PMC] [Abstract]
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  8. "Molecular characterization of a familial translocation implicates disruption of HDAC9 and possible position effect on TGFbeta2 in the pathogenesis of Peters' anomaly."Genomics 81:489-503(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Mechanisms for asporin function and regulation in articular cartilage."J. Biol. Chem. 282:32185-32192(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily."Science 257:369-373(1992) [PubMed] [Europe PMC] [Abstract]
  11. "An unusual feature revealed by the crystal structure at 2.2-A resolution of human transforming growth factor-beta 2."Nature 358:430-434(1992) [PubMed] [Europe PMC] [Abstract]
  12. "Two novel polymorphisms in the human transforming growth factor beta 2 gene."Genes Immun. 2:295-296(2001) [PubMed] [Europe PMC] [Abstract]
  13. "Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm." Nat. Genet. 44:922-927(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Whole exome sequencing for the identification of a new mutation in TGFB2 involved in a familial case of non-syndromic aortic disease."Clin. Chim. Acta 437:88-92(2014) [PubMed] [Europe PMC] [Abstract]