Superoxide Dismutase 3, Extracellular (SOD3)
[Edit]SOD-3; EC-SOD; Extracellular Superoxide Dismutase Cu-Zn
-90117.jpg)
Extracellular superoxide dismutase [Cu-Zn] encoded by the SOD3, isa member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen.
Extracellular Superoxide Dismutase 3,is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA117Ra01 | Recombinant Superoxide Dismutase 3, Extracellular (SOD3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA117Ra01 | Polyclonal Antibody to Superoxide Dismutase 3, Extracellular (SOD3) | WB; IHC; ICC; IP. |
| MAA117Ra21 | Monoclonal Antibody to Superoxide Dismutase 3, Extracellular (SOD3) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA117Ra | ELISA Kit for Superoxide Dismutase 3, Extracellular (SOD3) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Oryctolagus cuniculus (Rabbit)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA117Rb01 | Recombinant Superoxide Dismutase 3, Extracellular (SOD3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA117Rb01 | Active Superoxide Dismutase 3, Extracellular (SOD3) | Cell culture; Activity Assays. | |
| Antibodies | PAA117Rb51 | Polyclonal Antibody to Superoxide Dismutase 3, Extracellular (SOD3) | WB; IHC; ICC; IP. |
| MAA117Rb21 | Monoclonal Antibody to Superoxide Dismutase 3, Extracellular (SOD3) | WB; IHC; ICC; IP. | |
| PAA117Rb01 | Polyclonal Antibody to Superoxide Dismutase 3, Extracellular (SOD3) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA117Rb | ELISA Kit for Superoxide Dismutase 3, Extracellular (SOD3) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Isolation and sequence of complementary DNA encoding human extracellular superoxide dismutase."Proc. Natl. Acad. Sci. U.S.A. 84:6340-6344(1987) [PubMed] [Europe PMC] [Abstract]
- "Extracellular superoxide dismutase (SOD3): tissue-specific expression, genomic characterization, and computer-assisted sequence analysis of the human EC SOD gene."Genomics 22:162-171(1994) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "The site of nonenzymic glycation of human extracellular-superoxide dismutase in vitro."Free Radic. Biol. Med. 13:205-210(1992) [PubMed] [Europe PMC] [Abstract]
- "Extracellular superoxide dismutase."Int. J. Biochem. Cell Biol. 37:2466-2471(2005) [PubMed] [Europe PMC] [Abstract]
- "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
- "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
- "The structure of human extracellular copper-zinc superoxide dismutase at 1.7 A resolution: insights into heparin and collagen binding."J. Mol. Biol. 388:310-326(2009) [PubMed] [Europe PMC] [Abstract]
- "10-fold increase in human plasma extracellular superoxide dismutase content caused by a mutation in heparin-binding domain."J. Biol. Chem. 269:19163-19166(1994) [PubMed] [Europe PMC] [Abstract]
- "Molecular analysis of extracellular-superoxide dismutase gene associated with high level in serum."Jpn. J. Hum. Genet. 40:177-184(1995) [PubMed] [Europe PMC] [Abstract]
- "Substitution of glycine for arginine-213 in extracellular-superoxide dismutase impairs affinity for heparin and endothelial cell surface."Biochem. J. 313:235-239(1996) [PubMed] [Europe PMC] [Abstract]
- "An arginine-213 to glycine mutation in human extracellular-superoxide dismutase reduces susceptibility to trypsin-like proteinases."J. Biochem. 120:184-188(1996) [PubMed] [Europe PMC] [Abstract]