Osteoprotegerin (OPG)

[Edit]

TNFRSF11B; TNFRSF11-B; OCIF; OPG; TR1; Tumor Necrosis Factor Receptor Superfamily Member 11b; Osteoclastogenesis Inhibitory Factor

Osteoprotegerin (OPG)

Osteoprotegerin (OPG) is a cytokine, which can inhibit the production of osteoclasts. It is a member of the tumor necrosis factor (TNF) receptor superfamily. It is a basic glycoprotein comprising 401 amino acid residues arranged into 7 structural domains. It is found as either a 60 kDa monomer or 120 kDa dimer linked by disulfide bonds.Osteoprotegerin inhibits the differentiation of osteoclast precursors into osteoclasts and also regulates the resorption of osteoclasts in vitro and in vivo. Osteoprotegerin is a RANK homolog, and works by binding to RANKL on osteoblast/stromal cells, thus blocking the RANKL-RANK ligand interaction between osteoblast/stromal cells and osteoclast precursors. This has the effect of inhibiting the differentiation of the osteoclast precursor into a mature osteoclast.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA108Hu01 Recombinant Osteoprotegerin (OPG) Positive Control; Immunogen; SDS-PAGE; WB.
EPA108Hu61 Eukaryotic Osteoprotegerin (OPG) Positive Control; Immunogen; SDS-PAGE; WB.
APA108Hu01 Active Osteoprotegerin (OPG) Cell culture; Activity Assays.
Antibodies PAA108Hu01 Polyclonal Antibody to Osteoprotegerin (OPG) WB; IHC; ICC; IP.
MAA108Hu22 Monoclonal Antibody to Osteoprotegerin (OPG) WB; IHC; ICC; IP.
PAA108Hu06 Polyclonal Antibody to Osteoprotegerin (OPG) WB; IHC; ICC; IP.
Assay Kits SEA108Hu ELISA Kit for Osteoprotegerin (OPG) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA108Hu CLIA Kit for Osteoprotegerin (OPG) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA108Mu01 Recombinant Osteoprotegerin (OPG) Positive Control; Immunogen; SDS-PAGE; WB.
RPA108Mu02 Recombinant Osteoprotegerin (OPG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA108Mu01 Polyclonal Antibody to Osteoprotegerin (OPG) WB; IHC; ICC; IP.
PAA108Mu02 Polyclonal Antibody to Osteoprotegerin (OPG) WB; IHC; ICC; IP.
Assay Kits SEA108Mu ELISA Kit for Osteoprotegerin (OPG) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA108Mu CLIA Kit for Osteoprotegerin (OPG) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA108Ra01 Recombinant Osteoprotegerin (OPG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA108Ra01 Polyclonal Antibody to Osteoprotegerin (OPG) WB; IHC; ICC; IP.
MAA108Ra21 Monoclonal Antibody to Osteoprotegerin (OPG) WB; IHC; ICC; IP.
Assay Kits SEA108Ra ELISA Kit for Osteoprotegerin (OPG) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA108Po01 Recombinant Osteoprotegerin (OPG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA108Po01 Polyclonal Antibody to Osteoprotegerin (OPG) WB; IHC; ICC; IP.
MAA108Po21 Monoclonal Antibody to Osteoprotegerin (OPG) WB; IHC; ICC; IP.
Assay Kits SEA108Po ELISA Kit for Osteoprotegerin (OPG) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA108Cp01 Recombinant Osteoprotegerin (OPG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA108Cp01 Polyclonal Antibody to Osteoprotegerin (OPG) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Osteoprotegerin (OPG) CLIA Kit Customized Service Offer
n/a ELISA Kit for Osteoprotegerin (OPG) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA108Ga01 Recombinant Osteoprotegerin (OPG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA108Ga01 Polyclonal Antibody to Osteoprotegerin (OPG) WB; IHC; ICC; IP.
MAA108Ga01 Monoclonal Antibody to Osteoprotegerin (OPG) WB; IHC; ICC; IP.
Assay Kits SEA108Ga ELISA Kit for Osteoprotegerin (OPG) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Osteoprotegerin: a novel secreted protein involved in the regulation of bone density." Cell 89:309-319(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro."Endocrinology 139:1329-1337(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and characterization of the gene encoding human osteoprotegerin/osteoclastogenesis-inhibitory factor."Eur. J. Biochem. 254:685-691(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of monomeric and homodimeric forms of osteoclastogenesis inhibitory factor."Biochem. Biophys. Res. Commun. 245:382-387(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Cloning and expression of a novel mutated osteoprogerin/osteoclastogenesis inhibitory factor gene."Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 31:680-684(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis."Biochem. Biophys. Res. Commun. 234:137-142(1997) [PubMed] [Europe PMC] [Abstract]
  11. "Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL."J. Biol. Chem. 273:14363-14367(1998) [PubMed] [Europe PMC] [Abstract]
  12. "Characterization of structural domains of human osteoclastogenesis inhibitory factor."J. Biol. Chem. 273:5117-5123(1998) [PubMed] [Europe PMC] [Abstract]
  13. "Receptor activator of nuclear factor-kappaB ligand and osteoprotegerin: potential implications for the pathogenesis and treatment of malignant bone diseases."Cancer 92:460-470(2001) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of human RANKL complexed with its decoy receptor osteoprotegerin."J. Immunol. 189:245-252(2012) [PubMed] [Europe PMC] [Abstract]
  15. "A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype."Hum. Mol. Genet. 11:2119-2127(2002) [PubMed] [Europe PMC] [Abstract]