Interleukin 5 (IL5)
[Edit]E-CSF; ESGF; EDF; TRF; Colony-Stimulating Factor,Eosinophil; T-Cell replacing Factor; B Cell Differentiation Factor I; Eosinophil Differentiation Factor
-90078.jpg)
IL-5 is secreted by a restricted number of mesenchymal cell types. In its native state, mature IL-5 is synthesized as a 115 aa, highly glycosylated 22 kDa monomer that forms a 40-50 kDa disulfide-linked homodimer.
Although the content of carbohydrate is high, carbohydrate is not needed for bioactivity. Monomeric IL-5 has no activity and requires a homodimer for function, which is in contrast to the receptor-related IL-3 and GM-CSF cytokines that exist only as monomers. Just as one IL-3 and GM-CSF monomer binds to one receptor, one IL-5 homodimer is able to engage only one IL-5 receptor. It has been suggested that IL-5 (as a dimmer) undergoes a general conformational change after binding to one receptor molecule and this change precludes binding to a second receptor.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA078Hu01 | Recombinant Interleukin 5 (IL5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| EPA078Hu61 | Eukaryotic Interleukin 5 (IL5) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA078Hu01 | Active Interleukin 5 (IL5) | Cell culture; Activity Assays. | |
| APA078Hu61 | Active Interleukin 5 (IL5) | Cell culture; Activity Assays; In vivo assays. | |
| EPA078Hu41 | Eukaryotic Interleukin 5 (IL5) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| EPA078Hu62 | Eukaryotic Interleukin 5 (IL5) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA078Hu62 | Active Interleukin 5 (IL5) | Cell culture; Activity Assays. | |
| Antibodies | PAA078Hu01 | Polyclonal Antibody to Interleukin 5 (IL5) | WB; IHC; ICC; IP. |
| MAA078Hu22 | Monoclonal Antibody to Interleukin 5 (IL5) | WB | |
| MAA078Hu21 | Monoclonal Antibody to Interleukin 5 (IL5) | WB | |
| Assay Kits | SEA078Hu | ELISA Kit for Interleukin 5 (IL5) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA078Mu01 | Recombinant Interleukin 5 (IL5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA078Mu02 | Recombinant Interleukin 5 (IL5) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| EPA078Mu61 | Eukaryotic Interleukin 5 (IL5) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA078Mu61 | Active Interleukin 5 (IL5) | Cell culture; Activity Assays. | |
| Antibodies | PAA078Mu01 | Polyclonal Antibody to Interleukin 5 (IL5) | WB; IHC; ICC; IP. |
| PAA078Mu02 | Polyclonal Antibody to Interleukin 5 (IL5) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA078Mu | ELISA Kit for Interleukin 5 (IL5) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA078Ra01 | Recombinant Interleukin 5 (IL5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA078Ra01 | Polyclonal Antibody to Interleukin 5 (IL5) | WB; IHC; ICC; IP. |
| MAA078Ra21 | Monoclonal Antibody to Interleukin 5 (IL5) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA078Ra | ELISA Kit for Interleukin 5 (IL5) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Cavia (Guinea pig )
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA078Gu01 | Recombinant Interleukin 5 (IL5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA078Gu01 | Polyclonal Antibody to Interleukin 5 (IL5) | WB; IHC; ICC; IP. |
| MAA078Gu21 | Monoclonal Antibody to Interleukin 5 (IL5) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA078Gu | ELISA Kit for Interleukin 5 (IL5) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Oryctolagus cuniculus (Rabbit)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA078Rb01 | Recombinant Interleukin 5 (IL5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | n/a | Monoclonal Antibody to Interleukin 5 (IL5) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Interleukin 5 (IL5) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | SEA078Rb | ELISA Kit for Interleukin 5 (IL5) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rhesus monkey (Simian)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA078Si01 | Recombinant Interleukin 5 (IL5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA078Si01 | Polyclonal Antibody to Interleukin 5 (IL5) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Interleukin 5 (IL5) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Interleukin 5 (IL5) | ELISA Kit Customized Service Offer |
Organism species: Canis familiaris; Canine (Dog)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA078Ca01 | Recombinant Interleukin 5 (IL5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA078Ca01 | Polyclonal Antibody to Interleukin 5 (IL5) | WB; IHC; ICC; IP. |
| MAA078Ca21 | Monoclonal Antibody to Interleukin 5 (IL5) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA078Ca | ELISA Kit for Interleukin 5 (IL5) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA078Po01 | Recombinant Interleukin 5 (IL5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA078Po01 | Polyclonal Antibody to Interleukin 5 (IL5) | WB; IHC; ICC; IP. |
| MAA078Po21 | Monoclonal Antibody to Interleukin 5 (IL5) | WB; IHC; ICC; IP. | |
| MAA078Po22 | Monoclonal Antibody to Interleukin 5 (IL5) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA078Po | ELISA Kit for Interleukin 5 (IL5) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA078Bo01 | Recombinant Interleukin 5 (IL5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA078Bo01 | Polyclonal Antibody to Interleukin 5 (IL5) | WB; IHC; ICC; IP. |
| MAA078Bo21 | Monoclonal Antibody to Interleukin 5 (IL5) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA078Bo | ELISA Kit for Interleukin 5 (IL5) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Capra hircus; Caprine (Goat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA078Cp01 | Recombinant Interleukin 5 (IL5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA078Cp01 | Polyclonal Antibody to Interleukin 5 (IL5) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Interleukin 5 (IL5) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Interleukin 5 (IL5) | ELISA Kit Customized Service Offer |
Organism species: Equus caballus; Equine (Horse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA078Eq01 | Recombinant Interleukin 5 (IL5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA078Eq01 | Polyclonal Antibody to Interleukin 5 (IL5) | WB; IHC; ICC; IP. |
| MAA078Eq21 | Monoclonal Antibody to Interleukin 5 (IL5) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA078Eq | ELISA Kit for Interleukin 5 (IL5) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Chicken (Gallus)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA078Ga01 | Recombinant Interleukin 5 (IL5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA078Ga01 | Polyclonal Antibody to Interleukin 5 (IL5) | WB; IHC; ICC; IP. |
| MAA078Ga21 | Monoclonal Antibody to Interleukin 5 (IL5) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA078Ga | ELISA Kit for Interleukin 5 (IL5) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Cloning of cDNA for human T-cell replacing factor (interleukin-5) and comparison with the murine homologue."Nucleic Acids Res. 14:9149-9158(1986) [PubMed] [Europe PMC] [Abstract]
- "Molecular cloning and structure of the human interleukin-5 gene."J. Biol. Chem. 262:16580-16584(1987) [PubMed] [Europe PMC] [Abstract]
- "Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5)."Proc. Natl. Acad. Sci. U.S.A. 84:6629-6633(1987) [PubMed] [Europe PMC] [Abstract]
- "Isolation and characterization of lymphokine cDNA clones encoding mouse and human IgA-enhancing factor and eosinophil colony-stimulating factor activities: relationship to interleukin 5."Proc. Natl. Acad. Sci. U.S.A. 84:7388-7392(1987) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Structure of recombinant human interleukin 5 produced by Chinese hamster ovary cells."J. Biochem. 107:292-297(1990) [PubMed] [Europe PMC] [Abstract]
- "Human interleukin-5 expressed in Escherichia coli: assignment of the disulfide bridges of the purified unglycosylated protein."FEBS Lett. 283:61-64(1991) [PubMed] [Europe PMC] [Abstract]
- "A novel dimer configuration revealed by the crystal structure at 2.4-A resolution of human interleukin-5."Nature 363:172-176(1993) [PubMed] [Europe PMC] [Abstract]
- "Structure analysis of the IL-5 ligand-receptor complex reveals a wrench-like architecture for IL-5Ralpha."Structure 19:1864-1875(2011) [PubMed] [Europe PMC] [Abstract]