Glial Fibrillary Acidic Protein (GFAP)

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Intermediate Filament Protein

Glial Fibrillary Acidic Protein (GFAP)

GFAP) is an intermediate filament (IF) protein that is found in glial cells such as astrocytes. It is closely related to its non-epithelial family members, vimentin, desmin, and peripherin, which are all involved in the structure and function of the cell’s cytoskeleton. GFAP helps to maintain astrocyte mechanical strength, as well as the shape of cells.GFAP is expressed in the central nervous system in astrocyte cells. It is involved in many cellular functioning processes, such as cell structure and movement, cell communication, and the functioning of the blood brain barrier.

The predicted amino acid sequence indicated that GFAP shares structural similarities--particularly in the central rod domain and to a lesser degree in the carboxyl-terminal domain--with other IF proteins found in nonepithelial cell types.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA068Hu01 Recombinant Glial Fibrillary Acidic Protein (GFAP) Positive Control; Immunogen; SDS-PAGE; WB.
RPA068Hu02 Recombinant Glial Fibrillary Acidic Protein (GFAP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA068Hu01 Polyclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) WB; ICC; IHC-P; IHC-F; ELISA.
MAA068Hu22 Monoclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) WB; IHC; ICC; IP.
LAA068Hu71 Biotin-Linked Polyclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) WB; IHC; ICC.
LAA068Hu81 FITC-Linked Polyclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) WB; IHC; ICC; IF.
PAA068Hu02 Polyclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) WB; IHC; ICC; IP.
Assay Kits SEA068Hu ELISA Kit for Glial Fibrillary Acidic Protein (GFAP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA068Mu01 Recombinant Glial Fibrillary Acidic Protein (GFAP) Positive Control; Immunogen; SDS-PAGE; WB.
RPA068Mu02 Recombinant Glial Fibrillary Acidic Protein (GFAP) Positive Control; Immunogen; SDS-PAGE; WB.
RPA068Mu03 Recombinant Glial Fibrillary Acidic Protein (GFAP) Positive Control; Immunogen; SDS-PAGE; WB.
RPA068Mu04 Recombinant Glial Fibrillary Acidic Protein (GFAP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA068Mu01 Polyclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) WB; IHC; ICC; IP.
PAA068Mu02 Polyclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) WB; IHC; ICC; IP.
PAA068Mu03 Polyclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) WB; IHC; ICC; IP.
PAA068Mu04 Polyclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) WB; IHC; ICC; IP.
Assay Kits SEA068Mu ELISA Kit for Glial Fibrillary Acidic Protein (GFAP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA068Ra01 Recombinant Glial Fibrillary Acidic Protein (GFAP) Positive Control; Immunogen; SDS-PAGE; WB.
RPA068Ra02 Recombinant Glial Fibrillary Acidic Protein (GFAP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA068Ra01 Polyclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) WB; IHC; ICC; IP.
LAA068Ra71 Biotin-Linked Polyclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) WB; IHC; ICC.
LAA068Ra81 FITC-Linked Polyclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) WB; IHC; ICC; IF.
MAA068Ra21 Monoclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) WB; IHC; ICC; IP.
PAA068Ra02 Polyclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) WB; IHC; ICC; IP.
Assay Kits SEA068Ra ELISA Kit for Glial Fibrillary Acidic Protein (GFAP) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA068Ra CLIA Kit for Glial Fibrillary Acidic Protein (GFAP) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA068Bo01 Recombinant Glial Fibrillary Acidic Protein (GFAP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA068Bo01 Polyclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) WB; IHC; ICC; IP.
MAA068Bo21 Monoclonal Antibody to Glial Fibrillary Acidic Protein (GFAP) WB; IHC; ICC; IP.
Assay Kits SEA068Bo ELISA Kit for Glial Fibrillary Acidic Protein (GFAP) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "Characterization of human cDNA and genomic clones for glial fibrillary acidic protein."Brain Res. Mol. Brain Res. 7:277-286(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Human glial fibrillary acidic protein: complementary DNA cloning, chromosome localization, and messenger RNA expression in human glioma cell lines of various phenotypes."Cancer Res. 51:1553-1560(1991) [PubMed] [Europe PMC] [Abstract]
  4. "Human glial fibrillary acidic protein (GFAP): molecular cloning of the complete cDNA sequence and chromosomal localization (chromosome 17) of the GFAP gene."Acta Neuropathol. 83:569-578(1992) [PubMed] [Europe PMC] [Abstract]
  5. "Determination of the gene structure of human GFAP and absence of coding region mutations associated with frontotemporal dementia with parkinsonism linked to chromosome 17."Genomics 51:152-154(1998) [PubMed] [Europe PMC] [Abstract]
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  8. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "An RNA polymerase II promoter containing sequences upstream and downstream from the RNA startpoint that direct initiation of transcription from the same site."Proc. Natl. Acad. Sci. U.S.A. 87:4289-4293(1990) [PubMed] [Europe PMC] [Abstract]