≡

Fibroblast Growth Factor 1, Acidic (FGF1)

[Edit]

ECGF; AFGF; ECGFA; ECGFB; FGF-Alpha; FGFA; HBGF1; ECGFB; HBGF1; Acidic Fibroblast Growth Factor; heparin-binding growth factor 1; Endothelial Cell Growth Factor, Beta

Fibroblast Growth Factor 1, Acidic (FGF1)
CCC A032
HGNC 3665
MGI 95515
PubMed 22990650
RGD 2605
UniProt P05230
Wiki FGF1

Heparin-binding growth factor 1  is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.

This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Three alternatively spliced variants encoding different isoforms have been described.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA032Hu01 Recombinant Fibroblast Growth Factor 1, Acidic (FGF1) Positive Control; Immunogen; SDS-PAGE; WB.
APA032Hu01 Active Fibroblast Growth Factor 1, Acidic (FGF1) Cell culture; Activity Assays.
RPA032Hu02 Recombinant Fibroblast Growth Factor 1, Acidic (FGF1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA032Hu03 Recombinant Fibroblast Growth Factor 1, Acidic (FGF1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA032Hu04 Recombinant Fibroblast Growth Factor 1, Acidic (FGF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA032Hu01 Polyclonal Antibody to Fibroblast Growth Factor 1, Acidic (FGF1) WB; IHC; ICC; IP.
MAA032Hu22 Monoclonal Antibody to Fibroblast Growth Factor 1, Acidic (FGF1) WB; IHC; ICC; IP.
LAA032Hu81 FITC-Linked Polyclonal Antibody to Fibroblast Growth Factor 1, Acidic (FGF1) WB; IHC; ICC; IF.
LAA032Hu71 Biotin-Linked Polyclonal Antibody to Fibroblast Growth Factor 1, Acidic (FGF1) WB; IHC; ICC.
MAA032Hu21 Monoclonal Antibody to Fibroblast Growth Factor 1, Acidic (FGF1) WB; IHC; ICC; IP.
Assay Kits SEA032Hu ELISA Kit for Fibroblast Growth Factor 1, Acidic (FGF1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA032Hu CLIA Kit for Fibroblast Growth Factor 1, Acidic (FGF1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA032Mu01 Recombinant Fibroblast Growth Factor 1, Acidic (FGF1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA032Mu02 Recombinant Fibroblast Growth Factor 1, Acidic (FGF1) Positive Control; Immunogen; SDS-PAGE; WB.
APA032Mu01 Active Fibroblast Growth Factor 1, Acidic (FGF1) Cell culture; Activity Assays.
Antibodies PAA032Mu01 Polyclonal Antibody to Fibroblast Growth Factor 1, Acidic (FGF1) WB; IHC; ICC; IP.
PAA032Mu02 Polyclonal Antibody to Fibroblast Growth Factor 1, Acidic (FGF1) WB; IHC; ICC; IP.
Assay Kits SEA032Mu ELISA Kit for Fibroblast Growth Factor 1, Acidic (FGF1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA032Mu CLIA Kit for Fibroblast Growth Factor 1, Acidic (FGF1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA032Ra01 Recombinant Fibroblast Growth Factor 1, Acidic (FGF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA032Ra01 Polyclonal Antibody to Fibroblast Growth Factor 1, Acidic (FGF1) WB; IHC; ICC; IP.
LAA032Ra81 FITC-Linked Polyclonal Antibody to Fibroblast Growth Factor 1, Acidic (FGF1) WB; IHC; ICC; IF.
LAA032Ra71 Biotin-Linked Polyclonal Antibody to Fibroblast Growth Factor 1, Acidic (FGF1) WB; IHC; ICC.
MAA032Ra21 Monoclonal Antibody to Fibroblast Growth Factor 1, Acidic (FGF1) WB; IHC; ICC; IP.
Assay Kits SEA032Ra ELISA Kit for Fibroblast Growth Factor 1, Acidic (FGF1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA032Ra CLIA Kit for Fibroblast Growth Factor 1, Acidic (FGF1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA032Po01 Recombinant Fibroblast Growth Factor 1, Acidic (FGF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA032Po01 Polyclonal Antibody to Fibroblast Growth Factor 1, Acidic (FGF1) WB; IHC; ICC; IP.
LAA032Po81 FITC-Linked Polyclonal Antibody to Fibroblast Growth Factor 1, Acidic (FGF1) WB; IHC; ICC; IF.
LAA032Po71 Biotin-Linked Polyclonal Antibody to Fibroblast Growth Factor 1, Acidic (FGF1) WB; IHC; ICC.
MAA032Po21 Monoclonal Antibody to Fibroblast Growth Factor 1, Acidic (FGF1) WB; IHC; ICC; IP.
Assay Kits SEA032Po ELISA Kit for Fibroblast Growth Factor 1, Acidic (FGF1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA032Po CLIA Kit for Fibroblast Growth Factor 1, Acidic (FGF1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA032Bo01 Recombinant Fibroblast Growth Factor 1, Acidic (FGF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA032Bo01 Polyclonal Antibody to Fibroblast Growth Factor 1, Acidic (FGF1) WB; IHC; ICC; IP.
MAA032Bo21 Monoclonal Antibody to Fibroblast Growth Factor 1, Acidic (FGF1) WB; IHC; ICC; IP.
Assay Kits SEA032Bo ELISA Kit for Fibroblast Growth Factor 1, Acidic (FGF1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA032Bo CLIA Kit for Fibroblast Growth Factor 1, Acidic (FGF1) Chemiluminescent immunoassay for Antigen Detection.
CEA032Bo ELISA Kit for Fibroblast Growth Factor 1, Acidic (FGF1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA032Cp01 Recombinant Fibroblast Growth Factor 1, Acidic (FGF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA032Cp01 Polyclonal Antibody to Fibroblast Growth Factor 1, Acidic (FGF1) WB; IHC; ICC; IP.
MAA032Cp21 Monoclonal Antibody to Fibroblast Growth Factor 1, Acidic (FGF1) WB; IHC; ICC; IP.
Assay Kits SEA032Cp ELISA Kit for Fibroblast Growth Factor 1, Acidic (FGF1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA032Cp CLIA Kit for Fibroblast Growth Factor 1, Acidic (FGF1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Ovis aries; Ovine (Sheep)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA032Ov01 Recombinant Fibroblast Growth Factor 1, Acidic (FGF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA032Ov01 Polyclonal Antibody to Fibroblast Growth Factor 1, Acidic (FGF1) WB; IHC; ICC; IP.
Assay Kits SEA032Ov ELISA Kit for Fibroblast Growth Factor 1, Acidic (FGF1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA032Ga01 Recombinant Fibroblast Growth Factor 1, Acidic (FGF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA032Ga01 Polyclonal Antibody to Fibroblast Growth Factor 1, Acidic (FGF1) WB; IHC; ICC; IP.
MAA032Ga21 Monoclonal Antibody to Fibroblast Growth Factor 1, Acidic (FGF1) WB; IHC; ICC; IP.
Assay Kits SEA032Ga ELISA Kit for Fibroblast Growth Factor 1, Acidic (FGF1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA032Ga CLIA Kit for Fibroblast Growth Factor 1, Acidic (FGF1) Chemiluminescent immunoassay for Antigen Detection.
  1. "Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization."Science 233:541-545(1986) [PubMed] [Europe PMC] [Abstract]
  2. "Structural analysis of the gene for human acidic fibroblast growth factor."Biochem. Biophys. Res. Commun. 164:1121-1129(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning of the gene coding for human class 1 heparin-binding growth factor and its expression in fetal tissues."Mol. Cell. Biol. 9:2387-2395(1989) [PubMed] [Europe PMC] [Abstract]
  4. "Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1."Oncogene 5:755-762(1990) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning and sequence analysis of the human acidic fibroblast growth factor gene and its preservation in leukemia patients."Oncogene 6:1521-1529(1991) [PubMed] [Europe PMC] [Abstract]
  6. "An acidic fibroblast growth factor protein generated by alternate splicing acts like an antagonist."J. Exp. Med. 175:1073-1080(1992) [PubMed] [Europe PMC] [Abstract]
  7. "The expression of acidic fibroblast growth factor (heparin-binding growth factor-1) and cytokine genes in human cardiac allografts and T cells."Transplantation 56:1177-1182(1993) [PubMed] [Europe PMC] [Abstract]
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  11. "The gene for human acidic fibroblast growth factor encodes two upstream exons alternatively spliced to the first coding exon."Biochem. Biophys. Res. Commun. 171:7-13(1990) [PubMed] [Europe PMC] [Abstract]
  12. "Human class 1 heparin-binding growth factor: structure and homology to bovine acidic brain fibroblast growth factor."Biochemistry 25:4097-4103(1986) [PubMed] [Europe PMC] [Abstract]
  13. "The complete amino acid sequence of human brain-derived acidic fibroblast growth factor."Biochem. Biophys. Res. Commun. 138:611-617(1986) [PubMed] [Europe PMC] [Abstract]
  14. "Amino acid sequence of human acidic fibroblast growth factor."Biochem. Biophys. Res. Commun. 140:874-880(1986) [PubMed] [Europe PMC] [Abstract]
  15. "Human brain-derived acidic and basic fibroblast growth factors: amino terminal sequences and specific mitogenic activities."Biochem. Biophys. Res. Commun. 135:541-548(1986) [PubMed] [Europe PMC] [Abstract]
  16. "Partial molecular characterization of endothelial cell mitogens from human brain: acidic and basic fibroblast growth factors."FEBS Lett. 204:203-207(1986) [PubMed] [Europe PMC] [Abstract]
  17. "Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors."J. Biol. Chem. 266:16778-16785(1991) [PubMed] [Europe PMC] [Abstract]
  18. "Receptor specificity of the fibroblast growth factor family."J. Biol. Chem. 271:15292-15297(1996) [PubMed] [Europe PMC] [Abstract]
  19. "Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress."J. Biol. Chem. 276:25549-25557(2001) [PubMed] [Europe PMC] [Abstract]
  20. "Identification of ribosome-binding protein p34 as an intracellular protein that binds acidic fibroblast growth factor."J. Biol. Chem. 277:23864-23871(2002) [PubMed] [Europe PMC] [Abstract]
  21. "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
  22. "The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway."Cancer Lett. 267:67-74(2008) [PubMed] [Europe PMC] [Abstract]
  23. "Effect of human S100A13 gene silencing on FGF-1 transportation in human endothelial cells."J. Formos. Med. Assoc. 109:632-640(2010) [PubMed] [Europe PMC] [Abstract]
  24. "Cellular signaling by fibroblast growth factor receptors."Cytokine Growth Factor Rev. 16:139-149(2005) [PubMed] [Europe PMC] [Abstract]
  25. "Fibroblast growth factor signalling: from development to cancer."Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
  26. "Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnalpha1 and Kpnbeta1."Traffic 13:650-664(2012) [PubMed] [Europe PMC] [Abstract]
  27. "Three-dimensional structures of acidic and basic fibroblast growth factors."Science 251:90-93(1991) [PubMed] [Europe PMC] [Abstract]
  28. "X-ray crystal structure of human acidic fibroblast growth factor."Biochemistry 35:2086-2094(1996) [PubMed] [Europe PMC] [Abstract]
  29. "Structure of a heparin-linked biologically active dimer of fibroblast growth factor."Nature 393:812-817(1998) [PubMed] [Europe PMC] [Abstract]
  30. "Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity."Cell 101:413-424(2000) [PubMed] [Europe PMC] [Abstract]
  31. "Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin."Nature 407:1029-1034(2000) [PubMed] [Europe PMC] [Abstract]
  32. "Structural interactions of fibroblast growth factor receptor with its ligands."Proc. Natl. Acad. Sci. U.S.A. 97:49-54(2000) [PubMed] [Europe PMC] [Abstract]
  33. "Alternative type I and I' turn conformations in the beta8/beta9 beta-hairpin of human acidic fibroblast growth factor."Protein Sci. 11:459-466(2002) [PubMed] [Europe PMC] [Abstract]
  34. "Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity."Proc. Natl. Acad. Sci. U.S.A. 101:935-940(2004) [PubMed] [Europe PMC] [Abstract]
  35. "1H-NMR assignment and solution structure of human acidic fibroblast growth factor activated by inositol hexasulfate."J. Mol. Biol. 242:81-98(1994) [PubMed] [Europe PMC] [Abstract]
  36. "Three-dimensional structure of acidic fibroblast growth factor in solution: effects of binding to a heparin functional analog."J. Mol. Biol. 264:162-178(1996) [PubMed] [Europe PMC] [Abstract]
  37. "Solution structure of acidic fibroblast growth factor bound to 1,3, 6-naphthalenetrisulfonate: a minimal model for the anti-tumoral action of suramins and suradistas."J. Mol. Biol. 281:899-915(1998) [PubMed] [Europe PMC] [Abstract]
  38. "Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors."J. Biol. Chem. 285:11714-11729(2010) [PubMed] [Europe PMC] [Abstract]
  39. "The heterohexameric complex structure, a component in the non-classical pathway for fibroblast growth factor 1 (FGF1) secretion."J. Biol. Chem. 285:15464-15475(2010) [PubMed] [Europe PMC] [Abstract]