Selectin, Endothelium (SELE)

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CD62E; CD62-E; E-Selectin; ELAM; ELAM1; ESEL; SEL-E; E-LAM; E-LAM1; E-SEL; LECAM2; Endothelial Leukocyte Adhesion Molecule 1; CD62 Antigen-Like Family Member E

Selectin, Endothelium (SELE)

CD62E is also known as endothelial leukocyte adhesion molecule 1 (ELAM1) or E selectin. It is a type I membrane protein that belongs to the selectin family of surface molecules (along with CD62L and CD62P). Selectins are C type cell surface lectins that play a role in leukocyte adhesion to the blood vessel wall endothelium.

CD62E (E selectin) is an endothelial cell specific selectin that is expressed on cytokine induced endothelial cells only after activation with proinflammatory cytokines. In vitro experiments have shown that IL1, TNFalpha and bacterial wall components like lipopolysaccharides induce the transcription of CD62E in an NFkB dependent signalling cascade. CD62E has been associated with blood vessel endothelium in diverse inflammatory situations.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA029Hu01 Recombinant Selectin, Endothelium (SELE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA029Hu01 Polyclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IP.
MAA029Hu22 Monoclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IP.
Assay Kits SEA029Hu ELISA Kit for Selectin, Endothelium (SELE) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA029Hu CLIA Kit for Selectin, Endothelium (SELE) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA029Mu01 Recombinant Selectin, Endothelium (SELE) Positive Control; Immunogen; SDS-PAGE; WB.
RPA029Mu02 Recombinant Selectin, Endothelium (SELE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA029Mu01 Polyclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IP.
PAA029Mu02 Polyclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IP.
Assay Kits SEA029Mu ELISA Kit for Selectin, Endothelium (SELE) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA029Mu CLIA Kit for Selectin, Endothelium (SELE) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA029Ra01 Recombinant Selectin, Endothelium (SELE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA029Ra01 Polyclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IP.
MAA029Ra21 Monoclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IP.
Assay Kits SEA029Ra ELISA Kit for Selectin, Endothelium (SELE) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA029Ra CLIA Kit for Selectin, Endothelium (SELE) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA029Rb01 Recombinant Selectin, Endothelium (SELE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA029Rb51 Polyclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IP.
MAA029Rb21 Monoclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IP.
Assay Kits SEA029Rb ELISA Kit for Selectin, Endothelium (SELE) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA029Ca01 Recombinant Selectin, Endothelium (SELE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA029Ca01 Polyclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IP.
MAA029Ca21 Monoclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IP.
Assay Kits SEA029Ca ELISA Kit for Selectin, Endothelium (SELE) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA029Po01 Recombinant Selectin, Endothelium (SELE) Positive Control; Immunogen; SDS-PAGE; WB.
RPA029Po02 Recombinant Selectin, Endothelium (SELE) Positive Control; Immunogen; SDS-PAGE; WB.
RPA029Po03 Recombinant Selectin, Endothelium (SELE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA029Po01 Polyclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IP.
PAA029Po02 Polyclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IP.
LAA029Po81 FITC-Linked Polyclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IF.
LAA029Po71 Biotin-Linked Polyclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC.
PAA029Po03 Polyclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IP.
Assay Kits SEA029Po ELISA Kit for Selectin, Endothelium (SELE) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA029Bo01 Recombinant Selectin, Endothelium (SELE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA029Bo01 Polyclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Selectin, Endothelium (SELE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Selectin, Endothelium (SELE) ELISA Kit Customized Service Offer

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA029Cp01 Recombinant Selectin, Endothelium (SELE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA029Cp01 Polyclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Selectin, Endothelium (SELE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Selectin, Endothelium (SELE) ELISA Kit Customized Service Offer

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA029Eq01 Recombinant Selectin, Endothelium (SELE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA029Eq01 Polyclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Selectin, Endothelium (SELE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Selectin, Endothelium (SELE) ELISA Kit Customized Service Offer
  1. "Endothelial leukocyte adhesion molecule 1: direct expression cloning and functional interactions."Proc. Natl. Acad. Sci. U.S.A. 87:1673-1677(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins."Science 243:1160-1165(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1."J. Biol. Chem. 266:2466-2473(1991) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex."Science 250:1130-1132(1990) [PubMed] [Europe PMC] [Abstract]
  7. "Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins."J. Immunol. 181:1480-1490(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Modelling the carbohydrate recognition domain of human E-selectin."FEBS Lett. 319:5-11(1993) [PubMed] [Europe PMC] [Abstract]
  9. "Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains."Nature 367:532-538(1994) [PubMed] [Europe PMC] [Abstract]
  10. "Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1."Cell 103:467-479(2000) [PubMed] [Europe PMC] [Abstract]
  11. ErratumCell 105:971-971(2001)
  12. "E-selectin polymorphism and atherosclerosis: an association study."Hum. Mol. Genet. 3:1935-1937(1994) [PubMed] [Europe PMC] [Abstract]
  13. "DNA polymorphisms in adhesion molecule genes -- a new risk factor for early atherosclerosis."Hum. Genet. 97:15-20(1996) [PubMed] [Europe PMC] [Abstract]
  14. "A PstI polymorphism detects the mutation of serine-128 to arginine in CD 62E gene - a risk factor for coronary artery disease."J. Biomed. Sci. 6:18-21(1999) [PubMed] [Europe PMC] [Abstract]
  15. "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
  16. "Relationship between E-selectin L/F554 polymorphism and blood pressure in the Stanislas cohort."Hum. Genet. 107:58-61(2000) [PubMed] [Europe PMC] [Abstract]
  17. "E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under flow conditions."Arterioscler. Thromb. Vasc. Biol. 23:783-788(2003) [PubMed] [Europe PMC] [Abstract]
  18. "Implications of the E-selectin S128R mutation for drug discovery."Glycobiology 24:592-601(2014) [PubMed] [Europe PMC] [Abstract]