Erythropoietin (EPO)

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EP; Epoetin; Erythropoetin; Hematopoietin; Hemopoietin

Erythropoietin (EPO)

Erythropoietin is a glycoprotein hormone that controls erythropoiesis, or red blood cell production. It is a cytokine for erythrocyte (red blood cell) precursors in the bone marrow.Also called hematopoietin or hemopoietin, it is produced by the peritubular capillary endothelial cells in the kidney, and is the hormone that regulates red blood cell production.

It also has other known biological functions. For example, erythropoietin plays an important role in the brain's response to neuronal injury.EPO is also involved in the wound healing process.When exogenous EPO is used as a performance-enhancing drug, it is classified as an erythropoiesis-stimulating agent (ESA). Exogenous EPO can often be detected in blood, due to slight difference from the endogenous protein, for example in features of posttranslational modification.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA028Hu01 Recombinant Erythropoietin (EPO) Positive Control; Immunogen; SDS-PAGE; WB.
EPA028Hu61 Eukaryotic Erythropoietin (EPO) Positive Control; Immunogen; SDS-PAGE; WB.
APA028Hu01 Active Erythropoietin (EPO) Cell culture; Activity Assays.
APA028Hu61 Active Erythropoietin (EPO) Cell culture; Activity Assays.
APA028Hu62 Active Erythropoietin (EPO) Cell culture; Activity Assays.
Antibodies PAA028Hu01 Polyclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
MAA028Hu22 Monoclonal Antibody to Erythropoietin (EPO) WB,IHC
LAA028Hu71 Biotin-Linked Polyclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC.
PAA028Hu06 Polyclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
MAA028Hu23 Monoclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
MAA028Hu26 Monoclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
MAA028Hu21 Monoclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
MAA028Hu24 Monoclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
MAA028Hu25 Monoclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
Assay Kits SEA028Hu ELISA Kit for Erythropoietin (EPO) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA028Hu CLIA Kit for Erythropoietin (EPO) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA028Mu01 Recombinant Erythropoietin (EPO) Positive Control; Immunogen; SDS-PAGE; WB.
RPA028Mu02 Recombinant Erythropoietin (EPO) Positive Control; Immunogen; SDS-PAGE; WB.
RPA028Mu03 Recombinant Erythropoietin (EPO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA028Mu01 Polyclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
PAA028Mu02 Polyclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
PAA028Mu03 Polyclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
Assay Kits SEA028Mu ELISA Kit for Erythropoietin (EPO) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA028Mu CLIA Kit for Erythropoietin (EPO) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA028Ra01 Recombinant Erythropoietin (EPO) Positive Control; Immunogen; SDS-PAGE; WB.
APA028Ra61 Active Erythropoietin (EPO) Cell culture; Activity Assays.
EPA028Ra61 Eukaryotic Erythropoietin (EPO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA028Ra01 Polyclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
MAA028Ra21 Monoclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
Assay Kits SEA028Ra ELISA Kit for Erythropoietin (EPO) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA028Ra CLIA Kit for Erythropoietin (EPO) Chemiluminescent immunoassay for Antigen Detection.
AEA028Ra ELISA Kit for Anti-Erythropoietin Antibody (Anti-EPO) Enzyme-linked immunosorbent assay for Antibody Detection.

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA028Si01 Recombinant Erythropoietin (EPO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA028Si01 Polyclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
MAA028Si21 Monoclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
Assay Kits SEA028Si ELISA Kit for Erythropoietin (EPO) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA028Ca01 Recombinant Erythropoietin (EPO) Positive Control; Immunogen; SDS-PAGE; WB.
EPA028Ca61 Eukaryotic Erythropoietin (EPO) Positive Control; Immunogen; SDS-PAGE; WB.
APA028Ca61 Active Erythropoietin (EPO) Cell culture; Activity Assays.
Antibodies PAA028Ca01 Polyclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
MAA028Ca21 Monoclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
Assay Kits SEA028Ca ELISA Kit for Erythropoietin (EPO) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA028Po01 Recombinant Erythropoietin (EPO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA028Po01 Polyclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
MAA028Po21 Monoclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
Assay Kits SEA028Po ELISA Kit for Erythropoietin (EPO) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA028Bo01 Recombinant Erythropoietin (EPO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Erythropoietin (EPO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Erythropoietin (EPO) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Erythropoietin (EPO) CLIA Kit Customized Service Offer
n/a ELISA Kit for Erythropoietin (EPO) ELISA Kit Customized Service Offer

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA028Cp01 Recombinant Erythropoietin (EPO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA028Cp01 Polyclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Erythropoietin (EPO) CLIA Kit Customized Service Offer
n/a ELISA Kit for Erythropoietin (EPO) ELISA Kit Customized Service Offer

Organism species: Ovis aries; Ovine (Sheep)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA028Ov01 Recombinant Erythropoietin (EPO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Erythropoietin (EPO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Erythropoietin (EPO) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Erythropoietin (EPO) CLIA Kit Customized Service Offer
n/a ELISA Kit for Erythropoietin (EPO) ELISA Kit Customized Service Offer

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA028Eq01 Recombinant Erythropoietin (EPO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA028Eq01 Polyclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
MAA028Eq21 Monoclonal Antibody to Erythropoietin (EPO) WB; IHC; ICC; IP.
Assay Kits SEA028Eq ELISA Kit for Erythropoietin (EPO) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "Cloning and expression of the human erythropoietin gene."Proc. Natl. Acad. Sci. U.S.A. 82:7580-7584(1985) [PubMed] [Europe PMC] [Abstract]
  3. "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes."Genome Res. 8:1060-1073(1998) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Gene expression of mutant erythropoietin in hepatocellular carcinoma."Biochem. Biophys. Res. Commun. 195:717-722(1993) [PubMed] [Europe PMC] [Abstract]
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  8. "Isolation of human erythropoietin with monoclonal antibodies."J. Biol. Chem. 259:2707-2710(1984) [PubMed] [Europe PMC] [Abstract]
  9. "Comparative study of the asparagine-linked sugar chains of human erythropoietins purified from urine and the culture medium of recombinant Chinese hamster ovary cells."J. Biol. Chem. 263:3657-3663(1988) [PubMed] [Europe PMC] [Abstract]
  10. "Site-specific glycosylation of human recombinant erythropoietin: analysis of glycopeptides or peptides at each glycosylation site by fast atom bombardment mass spectrometry."Biochemistry 27:8618-8626(1988) [PubMed] [Europe PMC] [Abstract]
  11. "Structures and functional roles of the sugar chains of human erythropoietins."Glycobiology 1:337-346(1991) [PubMed] [Europe PMC] [Abstract]
  12. "Sugar profiling proves that human serum erythropoietin differs from recombinant human erythropoietin."Blood 98:3626-3634(2001) [PubMed] [Europe PMC] [Abstract]
  13. "Efficiency of signalling through cytokine receptors depends critically on receptor orientation."Nature 395:511-516(1998) [PubMed] [Europe PMC] [Abstract]
  14. "NMR structure of human erythropoietin and a comparison with its receptor bound conformation."Nat. Struct. Biol. 5:861-866(1998) [PubMed] [Europe PMC] [Abstract]
  15. "Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications." Proc. Natl. Acad. Sci. U.S.A. 105:6998-7003(2008) [PubMed] [Europe PMC] [Abstract]