Polyclonal Antibody to Cross Linked C-Telopeptide Of Type I Collagen (CTXI)



The antibody is a rabbit polyclonal antibody raised against CTXI. It has been selected for its ability to recognize CTXI in immunohistochemical staining and western blotting.


Western blotting: 0.5-2µg/mL;1:250-1000
Immunohistochemistry: 5-20µg/mL;1:25-100
Immunocytochemistry: 5-20µg/mL;1:25-100
Optimal working dilutions must be determined by end user.


Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.


The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.



Magazine Citations
journal of bone and mineral research Atp6v0d2 Is an Essential Component of the Osteoclast-Specific Proton Pump That Mediates Extracellular Acidification in Bone Resorption PubMed: PMC2672205
Bone Borage and fish oils lifelong supplementation decreases inflammation and improves bone health in a murine model of senile osteoporosis PubMed: 21664309
Trials Is there benefit in optimising heart failure treatment in over-80 year-old patients? (HF-80 study): study protocol for a randomized controlled trial. Trials: 1745-6215
Journal of Biological Chemistry TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation PubMed: 22773835
The Journal of Clinical Endocrinology & Metabolism A Mediterranean Diet Enriched with Olive Oil Is Associated with Higher Serum Total Osteocalcin Levels in Elderly Men at High Cardiovascular Risk PubMed: PMC3462931
Endocrinology Oxytocin Reverses Ovariectomy-Induced Osteopenia and Body Fat Gain Endocrine: Source
Am J Physiol Endocrinol Metab. DPP IV inhibitor treatment attenuates bone loss and improves mechanical bone strength in male diabetic rats Pubmed:25053403
The American Journal of Cardiology Relation of burden of myocardial fibrosis to malignant ventricular arrhythmias and outcomes in Fabry disease Pubmed:25073565
Rheumatology (Oxford). Bone resorption correlates with the frequency of CD5+ B cells in the blood of patients with rheumatoid arthritis Pubmed:25193807
XPO1/CRM1-Selective Inhibitors of Nuclear Export (SINE) reduce tumor spreading and improve overall survival in preclinical models of prostate cancer (PCa) Pubmed:25284315
Rheumatology International The presence of FCGR2B promoter or transmembrane region variant alleles leads to reduced serum IL-6 levels in rheumatoid arthritis Pubmed:25630523
The Journal of Biological Chemistry 5-azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival Pubmed:25691576
Scandinavian Journal of Clinical and Laboratory Investigation Osteocartilaginous metabolic markers change over a 3-week stage race in pro-cyclists PubMed: 26174975
AIDS Effects of renal tubular dysfunction on bone in tenofovir-exposed HIV-positive patients PubMed: 26372384
the journal of rheumatology Biomarkers in Remission According to Different Criteria in Patients with Rheumatoid Arthritis PubMed: 26472417
Int J Mol Med Curcumin alleviates glucocorticoid-induced osteoporosis through the regulation of the Wnt signaling pathway PubMed: 26677102
the journal of biological chemistry Mutation in Osteoactivin Promotes RANKL-Mediated Osteoclast Differentiation and Survival, but Inhibits Osteoclast Function PubMed: 25837253
frontiers in endocrinology Oxytocin reverses osteoporosis in a sex-dependent manner PubMed: 26042090
PLoS One.  The RIP1–RIP3 Complex Mediates Osteocyte Necroptosis after Ovariectomy in Rats pmc:PMC4795547
J Cell Physiol Lanthanum Chloride Attenuates Osteoclast Formation and Function Via the DownreCavia (Guinea pig )lation of Rankl-Induced Nf-κb and Nfatc1 Activities Pubmed:26060084
FASEB Journal N-Homocysteinylation impairs collagen cross-linking in cystathionine β-synthase-deficient mice: a novel mechanism of connective tissue abnormalities. pubmed:27530978
Metabolism. High FGF21 levels are associated with altered bone homeostasis in HIV-1-infected patients. pubmed:28521869
journal of science and medicine in sport The effect of calcium and vitamin D supplementation on bone health of male Jockeys. pubmed:27568072
Chemico-Biological Interactions Ginsenosides Rg3 attenuates glucocorticoid-induced osteoporosis through regulating BMP-2/BMPR1A/Runx2 signaling pathway pubmed:27387537
Epilepsy Research The effect of lamotrigine and phenytoin on bone turnover and bone strength: A prospective study in Wistar rats pubmed:27838501
Bone Reduced femoral bone mass in both diet-induced and genetic hyperlipidemia mice pubmed:27669658
Journal of Vascular Surgery A potential role for glycated cross-links in abdominal aortic aneurysm disease. pubmed:27624703
Institute of Pharmacology Effects of long-term administration of pantoprazole on bone mineral density in young male rats. pubmed:27552060
Biomedicine & Pharmacotherapy Anti-osteoporotic effects of an antidepressant tianeptine on ovariectomized rats S0753332216322752
European Journal of Pharmacology Cannabidiol administration reduces sublesional cancellous bone loss in rats with severe spinal cord injury pubmed:28479140
APPLIED SPECTROSCOPY Side-Effects of Convulsive Seizures and Anti-Seizure Therapy on Bone in a Rat Model of Epilepsy pubmed:28905646
Clinical Nutrition Obesity status influences the relationship among serum osteocalcin, iron stores and insulin sensitivity pubmed:29050649
Oncotarget A novel osteoporosis model with ascorbic acid deficiency in Akr1A1 gene knockout mice. pubmed:28060768
中国骨质疏松杂志 骨形成指标PINP 与骨吸收指标β-CTX 在2 型糖尿病合并骨质疏松中作用的研究. 10.3969/j.issn.1006-7108.2017.03.009
BioMed Research International Optimization of the Time Window of Interest in Ovariectomized Imprinting Control Region Mice for Antiosteoporosis Research pubmed:29119115
Cell Death And Differentiation TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42 Pubmed:29358671
Journal of Periodontology  The role of androgens on periodontal repair in female rats Pubmed:29683499
Life Sciences Myricetin ameliorates glucocorticoid-induced osteoporosis through the ERK signaling pathway Pubmed:29883721
European Journal of Pharmacology The effect of levetiracetam on rat bone mineral density, bone structure and biochemical markers of bone metabolism Pubmed:29428468
Journal of Clinical Densitometry Geometric and mechanical bone response to a multidisciplinary weight loss intervention in adolescents with obesity: The ADIBOX study Pubmed:30076009
Pharmacology Effects of Amlodipine on Bone Metabolism in Orchidectomised Spontaneously Hypertensive Rats Pubmed:29898457
Experimental and Therapeutic Medicine Liraglutide exerts a bone‑protective effect in ovariectomized rats with streptozotocin‑induced diabetes by inhibiting osteoclastogenesis Pubmed:29805533
Experimental and Therapeutic Medicine Combination therapy with BMP‑2 and psoralen enhances fracture healing in ovariectomized mice 10.3892:etm.2018.6353
Tumor Biology Dual PI3 K/mTOR inhibition reduces prostate cancer bone engraftment altering tumor-induced bone remodeling Pubmed:29687745
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