Discs Overgrown Protein Kinase (DCO)


DBT; Protein double-time

Discs Overgrown Protein Kinase (DCO)

The discs overgrown gene encodes a homolog of the Casein kinase I(delta)/(epsilon) subfamily and is identical to the double-time gene. However, in contrast to the weak double-time alleles, which appear to affect only the circadian rhythm, discs overgrown alleles, including bona fide null alleles, show strong effects on cell survival and growth control in imaginal discs. Analysis of their phenotypes and molecular lesions suggests that the Discs overgrown protein is a crucial component in the mechanism that links cell survival during proliferation to growth arrest in imaginal discs. This work provides the first analysis in a multicellular organism of Casein kinase I(delta)/(epsilon) functions necessary for survival. Since the amino acid sequences and three-dimensional structures of Casein kinase I(delta)/(epsilon) enzymes are highly conserved, the results suggest that these proteins may also function in controlling cell growth and survival in other organisms.

Organism species: D. melanogaster (Fruit fly)

Proteins n/a Recombinant Discs Overgrown Protein Kinase (DCO) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Discs Overgrown Protein Kinase (DCO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Discs Overgrown Protein Kinase (DCO) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Discs Overgrown Protein Kinase (DCO) CLIA Kit Customized Service Offer
n/a ELISA Kit for Discs Overgrown Protein Kinase (DCO) ELISA Kit Customized Service Offer