MT-RNR2 Like Protein 4 (MTRNR2L4)

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HN4; Humanin-Like Protein 4

MT-RNR2 Like Protein 4 (MTRNR2L4)
MTRNR2L4 Belongs to the humanin family.Highly expressed in testis. Also expressed in kidney, heart, skeletal muscles and brain. Humanin (HN) is a recently identified neuroprotective and antiapoptotic peptide derived from a portion of the mitochondrial MT-RNR2 gene. The existence of 13 MT-RNR2-like nuclear loci predicted to maintain the open reading frames of 15 distinct full-length HN-like peptides. At least ten of these nuclear genes are expressed in human tissues, and respond to staurosporine (STS) and beta-carotene. Sequence comparisons of the nuclear HN isoforms and their homologues in other species reveal two consensus motifs, encompassing residues 5–11 (GFS/NCLLL), and 14–19 (SEIDLP/S). Proline vs serine in position 19 may determine whether the peptide is secreted or not, while threonine in position 13 may be important for cell surface receptor binding.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant MT-RNR2 Like Protein 4 (MTRNR2L4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to MT-RNR2 Like Protein 4 (MTRNR2L4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to MT-RNR2 Like Protein 4 (MTRNR2L4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for MT-RNR2 Like Protein 4 (MTRNR2L4) CLIA Kit Customized Service Offer
n/a ELISA Kit for MT-RNR2 Like Protein 4 (MTRNR2L4) ELISA Kit Customized Service Offer
  1. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Evidence for potential functionality of nuclearly-encoded humanin isoforms."Genomics 94:247-256(2009) [PubMed] [Europe PMC] [Abstract]