Von Willebrand Factor A Domain Containing Protein 5B2 (vWA5B2)

VWA5B2 Contains 1 VIT domain.Contains 1 VWFA domain.The collagen binding site of alpha2beta1 has been localized to the alpha2 von Willebrand Factor type A (VWFA) domain (A-domain or I-domain) and the residues responsible for the interaction with collagen have been mapped.

Recombinant alpha2-E318W VWFA domain showed elevated and specific binding to collagen I compared with the wild-type. Side chain hydrophobicity was important for the gain-of-function as elevated binding was seen with E318I and E318Y, but not with E318R. A novel gain-of-function mutation of the integrin alpha2 VWFA domain.