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Mitochondrial Calcium Uniporter (MCU)

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CCDC109A; C10orf42; Coiled Coil Domain Containing Protein 109A

Mitochondrial Calcium Uniporter (MCU)
CCC U127
HGNC 23526
MGI 3026965
PubMed 21685886
RGD 1589771
UniProt Q8NE86
CCDC109A, that call 'mitochondrial calcium uniporter' (MCU). MCU forms oligomers in the mitochondrial inner membrane, physically interacts with MICU1, and resides within a large molecular weight complex. Silencing MCU in cultured cells or in vivo in mouse liver severely abrogates mitochondrial Ca(2+) uptake, whereas mitochondrial respiration and membrane potential remain fully intact.
MCU has two predicted transmembrane helices, which are separated by a highly conserved linker facing the intermembrane space. Acidic residues in this linker are required for its full activity. However, an S259A point mutation retains function but confers resistance to Ru360, the most potent inhibitor of the uniporter.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitochondrial Calcium Uniporter (MCU) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitochondrial Calcium Uniporter (MCU) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitochondrial Calcium Uniporter (MCU) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitochondrial Calcium Uniporter (MCU) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitochondrial Calcium Uniporter (MCU) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitochondrial Calcium Uniporter (MCU) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitochondrial Calcium Uniporter (MCU) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitochondrial Calcium Uniporter (MCU) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitochondrial Calcium Uniporter (MCU) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitochondrial Calcium Uniporter (MCU) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitochondrial Calcium Uniporter (MCU) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitochondrial Calcium Uniporter (MCU) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitochondrial Calcium Uniporter (MCU) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitochondrial Calcium Uniporter (MCU) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitochondrial Calcium Uniporter (MCU) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  5. "A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter."Nature 476:336-340(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter."Nature 476:341-345(2011) [PubMed] [Europe PMC] [Abstract]
  7. "MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival."Cell 151:630-644(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Mitochondrial Ca2+ uptake 1 (MICU1) and mitochondrial ca2+ uniporter (MCU) contribute to metabolism-secretion coupling in clonal pancreatic beta-cells."J. Biol. Chem. 287:34445-34454(2012) [PubMed] [Europe PMC] [Abstract]
  9. "MCUR1 is an essential component of mitochondrial Ca(2+) uptake that regulates cellular metabolism."Nat. Cell Biol. 14:1336-1343(2012) [PubMed] [Europe PMC] [Abstract]
  10. "The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic beta-cells."PLoS ONE 7:E39722-E39722(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Mitochondrial Ca2+ uptake contributes to buffering cytoplasmic Ca2+ peaks in cardiomyocytes."Proc. Natl. Acad. Sci. U.S.A. 109:12986-12991(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Evolutionary diversity of the mitochondrial calcium uniporter."Science 336:886-886(2012) [PubMed] [Europe PMC] [Abstract]
  13. "MICU1 motifs define mitochondrial calcium uniporter binding and activity."Cell Rep. 5:1576-1588(2013) [PubMed] [Europe PMC] [Abstract]
  14. "EMRE is an essential component of the mitochondrial calcium uniporter complex."Science 342:1379-1382(2013) [PubMed] [Europe PMC] [Abstract]
  15. "MICU1 and MICU2 finely tune the mitochondrial Ca(2+) uniporter by exerting opposite effects on MCU activity."Mol. Cell 53:726-737(2014) [PubMed] [Europe PMC] [Abstract]