Glutaredoxin, Cysteine Rich 2 (GRXCR2)

GRXCR2 belongs to the GRXCR1 family. GRXCR1is a deduced 290-amino acid protein containing a putative glutaredoxin catalytic domain and a cysteine-rich C-terminal region. The glutaredoxin domain is predicted to function in the reversible S-glutathionylation of proteins. Quantitative PCR detected high GRXCR1 expression in fetal cochlea, moderate expression in adult testis, low expression in fetal heart and adult duodenum and brain, and little to no expression in other adult and fetal tissues examined.Grxcr1 was expressed in sensory epithelial of the mouse inner ear and localized along the length of stereocilia of auditory and vestibular hair cells in mouse cochlear explants. It also localized along the length of actin filament-rich structures in filopodia in monkey fibroblasts and in microvilli at the apical surface of porcine kidney epithelial cells.