Keratin Associated Protein 4-6 (KRTAP4-6)

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KAP4.6; KAP4.15; Ultrahigh sulfur keratin-associated protein 4.15

Keratin Associated Protein 4-6 (KRTAP4-6)
KRTAP4-6 is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the ultrahigh sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Keratin Associated Protein 4-6 (KRTAP4-6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Keratin Associated Protein 4-6 (KRTAP4-6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Keratin Associated Protein 4-6 (KRTAP4-6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Keratin Associated Protein 4-6 (KRTAP4-6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Keratin Associated Protein 4-6 (KRTAP4-6) ELISA Kit Customized Service Offer
  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21."J. Biol. Chem. 276:19440-19451(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Size polymorphisms in the human ultrahigh sulfur hair keratin-associated protein 4, KAP4, gene family."J. Invest. Dermatol. 124:1111-1118(2005) [PubMed] [Europe PMC] [Abstract]