Taste Receptor Type 2 Member 45 (TAS2R45)

[Edit]

GPR59; G Protein-Coupled Receptor 59

Taste Receptor Type 2 Member 45 (TAS2R45)
TAS2R45 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway. The diversity and evolution of bitter taste perception in mammals is not well understood. A phylogenetic analysis of the T2R genes suggests that they can be classified into three main groups, which are designated A, B, and C. Interestingly, while the one-to-one gene orthology between the human and mouse is common to group B and C genes, group A genes show a pattern of species- or lineage-specific duplication. It is possible that group B and C genes are necessary for detecting bitter tastants common to both humans and mice, whereas group A genes are used for species-specific bitter tastants.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Taste Receptor Type 2 Member 45 (TAS2R45) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Taste Receptor Type 2 Member 45 (TAS2R45) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Taste Receptor Type 2 Member 45 (TAS2R45) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Taste Receptor Type 2 Member 45 (TAS2R45) CLIA Kit Customized Service Offer
n/a ELISA Kit for Taste Receptor Type 2 Member 45 (TAS2R45) ELISA Kit Customized Service Offer
  1. "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides."Nat. Genet. 32:397-401(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Receptors for bitter and sweet taste."Curr. Opin. Neurobiol. 12:366-371(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular mechanisms of bitter and sweet taste transduction."J. Biol. Chem. 277:1-4(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways."Cell 112:293-301(2003) [PubMed] [Europe PMC] [Abstract]