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Small Proline Rich Protein 2G (SPRR2G)

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Small Proline Rich Protein 2G (SPRR2G)
CCC T051
HGNC 11267
PubMed 12584609
UniProt Q9BYE4
SPRR2G, a member of the SPRRs family preferentially expressed in the suprabasal cells of keratinized epithelia, and localized essentially in the spinous cells. A whole set of genes linked to DNA remodeling and cell proliferation was also up-regulated. On the other hand, the Small Proline-Rich Protein 2G (SPRR2G) and S100 calcium binding protein P (S100P) andKeratin 1B genes were down-regulated by DHEA. Additionally, desmosome-associated corneodesmosin (Cdsn), a late marker of terminal differentiation of keratinocytes as well as Claudin-8 were also downregulated in the group of DHEA 2% measured after 8 weeks of treatment. Finally, the expression of two other genes involved in terminal differentiation of keratinocytes, namely the Late envelope protein 7 (LEP7) and the Jagged 1 (JAG1) genes, were also downregulated by DHEA.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Proline Rich Protein 2G (SPRR2G) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Proline Rich Protein 2G (SPRR2G) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Proline Rich Protein 2G (SPRR2G) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Proline Rich Protein 2G (SPRR2G) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Proline Rich Protein 2G (SPRR2G) ELISA Kit Customized Service Offer
  1. "Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function."J. Biol. Chem. 276:19231-19237(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]