Down Syndrome Critical Region Gene 9 (DSCR9)

[Edit]

Down Syndrome Critical Region Gene 9 (DSCR9)
DSCR9 and DSCR10, in the so-called Down Syndrome Critical Region (DSCR) by computational gene prediction and subsequent cDNA cloning. Both DSCR9 and DSCR10 are expressed preferentially in testis and encode functionally unknown proteins with 149 and 87 amino acid residues, respectively. Zoo blot analysis suggested that both genes are exclusive to primate genomes such as chimpanzee, gorilla, orangutan, crab-eating monkey and African green monkey but are not present in other non-primate mammals including mouse, dog, cat, and chicken. Comparative genomic sequence analysis of DSCR9 and DSCR10 with the corresponding mouse syntenic region confirmed the lack of these genes in the mouse. These results strongly suggest that DSCR9 and DSCR10 have emerged as a new class of gene in the primate lineage during evolution.

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Down Syndrome Critical Region Gene 9 (DSCR9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Down Syndrome Critical Region Gene 9 (DSCR9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Down Syndrome Critical Region Gene 9 (DSCR9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Down Syndrome Critical Region Gene 9 (DSCR9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Down Syndrome Critical Region Gene 9 (DSCR9) ELISA Kit Customized Service Offer
  1. "Identification of two novel primate-specific genes in DSCR."DNA Res. 9:89-97(2002) [PubMed] [Europe PMC] [Abstract]