POTE Ankyrin Domain Family, Member C (POTEC)

POTEC, Belongs to the POTE family. Expressed in prostate and testis. The POTE gene family is composed of 13 paralogs and likely evolved by duplications and remodeling of the human genome. One common property of POTE proteins is their localization on the inner aspect of the plasma membrane.

POTE is a primate-specific gene family composed of 13 closely related paralogs dispersed among eight chromosomes. Human genome sequence analysis suggests that all the human POTE genes evolved by duplications and remodeling of the genome from an ancestral gene, ANKRD26. POTE is expressed in many cancers (prostate, colon, lung, breast, ovary and pancreas) but in a limited number of normal organs. The preferential expression of different POTE paralogs in certain human cancers suggests a role in carcinogenesis.