![Sex Comb On Midleg Like Protein 3 (SCML3)](/upload/item/img/Sex-Comb-On-Midleg-Like-Protein-3-(SCML3)-86479.jpg)
Scmh1, a mammalian homolog of Drosophila Sex comb on midleg, is a constituent of the mammalian Polycomb repressive complexes 1 (Prc1). Scmh1 was shown to be excluded from the XY body at late pachytene, together with other Prc1 components such as Phc1, Phc2, Rnf110 (Pcgf2), Bmi1 and Cbx2. Apoptotic elimination of Scmh1 spermatocytes is accompanied by the preceding failure of several specific chromatin modifications at the XY body, whereas synapsis of homologous autosomes is not affected. It is therefore suggested that Scmh1 is involved in regulating the sequential changes in chromatin modifications at the XY chromatin domain of the pachytene spermatocytes. Restoration of defects in Scmh1 spermatocytes by Phc2 mutation indicates that Scmh1 exerts its molecular functions via its interaction with Prc1.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Sex Comb On Midleg Like Protein 3 (SCML3) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Sex Comb On Midleg Like Protein 3 (SCML3) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Sex Comb On Midleg Like Protein 3 (SCML3) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Sex Comb On Midleg Like Protein 3 (SCML3) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Sex Comb On Midleg Like Protein 3 (SCML3) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Sex Comb On Midleg Like Protein 3 (SCML3) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Sex Comb On Midleg Like Protein 3 (SCML3) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Sex Comb On Midleg Like Protein 3 (SCML3) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Sex Comb On Midleg Like Protein 3 (SCML3) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Sex Comb On Midleg Like Protein 3 (SCML3) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Sex Comb On Midleg Like Protein 3 (SCML3) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Sex Comb On Midleg Like Protein 3 (SCML3) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Sex Comb On Midleg Like Protein 3 (SCML3) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Sex Comb On Midleg Like Protein 3 (SCML3) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Sex Comb On Midleg Like Protein 3 (SCML3) | ELISA Kit Customized Service Offer |
- "The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34."Gene 237:185-191(1999) [PubMed] [Europe PMC] [Abstract] and Skeletal muscle and Muscle.
- "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans."Mol. Cell. Biol. 22:6070-6078(2002) [PubMed] [Europe PMC] [Abstract]