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DnaJ/HSP40 Homolog Subfamily C, Member 13 (DNAJC13)

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RME8; Required For Receptor-Mediated Endocytosis 8

DnaJ/HSP40 Homolog Subfamily C, Member 13 (DNAJC13)
CCC S130
HGNC 30343
MGI 2676368
PubMed 16179350
UniProt O75165
Wiki DNAJC13
DNAJC13, Contains 1 J domain. DnaJ/Hsp40 proteins have been preserved throughout evolution and are important for protein translation, folding, unfolding, translocation, and degradation, primarily by stimulating the ATPase activity of chaperone proteins, Hsp70s. Because the ATP hydrolysis is essential for the activity of Hsp70s, DnaJ/Hsp40 proteins actually determine the activity of Hsp70s by stabilizing their interaction with substrate proteins. DnaJ/Hsp40 proteins all contain the J domain through which they bind to Hsp70s and can be categorized into three groups, depending on the presence of other domains. Six DnaJ homologs have been identified in Escherichia coli and 22 in Saccharomyces cerevisiae. Genome-wide analysis has revealed 41 DnaJ/Hsp40 family members in humans.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DnaJ/HSP40 Homolog Subfamily C, Member 13 (DNAJC13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DnaJ/HSP40 Homolog Subfamily C, Member 13 (DNAJC13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DnaJ/HSP40 Homolog Subfamily C, Member 13 (DNAJC13) Polyclonal Antibody Customized Service Offer
Assay Kits SES130Hu ELISA Kit for DnaJ/HSP40 Homolog Subfamily C, Member 13 (DNAJC13) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DnaJ/HSP40 Homolog Subfamily C, Member 13 (DNAJC13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DnaJ/HSP40 Homolog Subfamily C, Member 13 (DNAJC13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DnaJ/HSP40 Homolog Subfamily C, Member 13 (DNAJC13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DnaJ/HSP40 Homolog Subfamily C, Member 13 (DNAJC13) CLIA Kit Customized Service Offer
n/a ELISA Kit for DnaJ/HSP40 Homolog Subfamily C, Member 13 (DNAJC13) ELISA Kit Customized Service Offer
  1. "The DnaJ-domain protein RME-8 functions in endosomal trafficking."J. Biol. Chem. 280:40135-40143(2005) [PubMed] [Europe PMC] [Abstract]
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  3. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human RME-8 is involved in membrane trafficking through early endosomes."Cell Struct. Funct. 33:35-50(2008) [PubMed] [Europe PMC] [Abstract]
  7. "RME-8 regulates trafficking of the epidermal growth factor receptor."FEBS Lett. 582:961-966(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "RME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation."J. Cell Sci. 127:2053-2070(2014) [PubMed] [Europe PMC] [Abstract]