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Male Specific Lethal 1 Homolog (MSL1)

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MSL1L1; Male-specific lethal 1-like 1

Male Specific Lethal 1 Homolog (MSL1)
CCC R749
HGNC 27905
MGI 1921276
PubMed 23084835
RGD 1564778
UniProt Q68DK7
hMSL contains homologs of the Drosophila dosage compensation proteins MOF, MSL1, MSL2, and MSL3. This complex shows strong specificity for histone H4 lysine 16 in chromatin in vitro, and RNA interference-mediated knockdown experiments reveal that it is responsible for the majority of H4 acetylation at lysine 16 in the cell. hMOF is a component of additional complexes, forming associations with host cell factor 1 and a protein distantly related to MSL1 (hMSL1v1).
Reduction in the levels of hMSLs and acetylation of H4 at lysine 16 are correlated with reduced transcription of some genes and with a G(2)/M cell cycle arrest. This is of particular interest given the recent correlation of global loss of acetylation of lysine 16 in histone H4 with tumorigenesis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Male Specific Lethal 1 Homolog (MSL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Male Specific Lethal 1 Homolog (MSL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Male Specific Lethal 1 Homolog (MSL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Male Specific Lethal 1 Homolog (MSL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Male Specific Lethal 1 Homolog (MSL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Male Specific Lethal 1 Homolog (MSL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Male Specific Lethal 1 Homolog (MSL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Male Specific Lethal 1 Homolog (MSL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Male Specific Lethal 1 Homolog (MSL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Male Specific Lethal 1 Homolog (MSL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Male Specific Lethal 1 Homolog (MSL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Male Specific Lethal 1 Homolog (MSL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Male Specific Lethal 1 Homolog (MSL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Male Specific Lethal 1 Homolog (MSL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Male Specific Lethal 1 Homolog (MSL1) ELISA Kit Customized Service Offer
  1. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates."J. Biol. Chem. 280:5004-5012(2005) [PubMed] [Europe PMC] [Abstract]
  5. "A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16."Mol. Cell. Biol. 25:9175-9188(2005) [PubMed] [Europe PMC] [Abstract]
  6. ErratumMol. Cell. Biol. 26:387-387(2006)
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage."J. Cell. Physiol. 221:594-602(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation."Mol. Cell 43:132-144(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1."Nat. Struct. Mol. Biol. 18:142-149(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex."Cell Res. 22:1078-1081(2012) [PubMed] [Europe PMC] [Abstract]
  16. "Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila."Mol. Cell 48:587-600(2012) [PubMed] [Europe PMC] [Abstract]