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Extended Synaptotagmin Like Protein 2 (ESYT2)

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FAM62B; CHR2SYT; Family With Sequence Similarity 62 (C2 Domain Containing), Member B

Extended Synaptotagmin Like Protein 2 (ESYT2)
CCC R020
HGNC 22211
MGI 1261845
PubMed 24013099
UniProt A0FGR8
ESYT2 belongs to the extended synaptotagmin family.Widely expressed with high level in cerebellum.May play a role as calcium-regulated intrinsic membrane protein.
Synaptotagmin genes are found in animal genomes and are known to function in the nervous system. Genes with a similar domain architecture as well as sequence similarity to synaptotagmin C2 domains have also been found in plant genomes. The plant genes share an additional region of sequence similarity with a group of animal genes named FAM62. FAM62 genes also have a similar domain architecture. Little is known about the functions of the plant genes and animal FAM62 genes. Genes encoding proteins with N-terminal-transmembrane-C2 domain architectures resembling synaptotagmins, are widespread in eukaryotes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Extended Synaptotagmin Like Protein 2 (ESYT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Extended Synaptotagmin Like Protein 2 (ESYT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Extended Synaptotagmin Like Protein 2 (ESYT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Extended Synaptotagmin Like Protein 2 (ESYT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Extended Synaptotagmin Like Protein 2 (ESYT2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Extended Synaptotagmin Like Protein 2 (ESYT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Extended Synaptotagmin Like Protein 2 (ESYT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Extended Synaptotagmin Like Protein 2 (ESYT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Extended Synaptotagmin Like Protein 2 (ESYT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Extended Synaptotagmin Like Protein 2 (ESYT2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Extended Synaptotagmin Like Protein 2 (ESYT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Extended Synaptotagmin Like Protein 2 (ESYT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Extended Synaptotagmin Like Protein 2 (ESYT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Extended Synaptotagmin Like Protein 2 (ESYT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Extended Synaptotagmin Like Protein 2 (ESYT2) ELISA Kit Customized Service Offer
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  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Extended-synaptotagmin-2 mediates FGF receptor endocytosis and ERK activation in vivo."Dev. Cell 19:426-439(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "PI(4,5)P(2)-dependent and Ca(2+)-regulated ER-PM interactions mediated by the extended synaptotagmins."Cell 153:1494-1509(2013) [PubMed] [Europe PMC] [Abstract]
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  20. "Solution structure of the third C2 domain of KIAA1228 protein."Submitted (OCT-2006) to the PDB data bank
  21. "Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer."Nature 510:552-555(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Structure and Ca(2+)-binding properties of the tandem C(2) domains of E-Syt2."Structure 22:269-280(2014) [PubMed] [Europe PMC] [Abstract]