Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1)
[Edit]HPIP; Pre-B-cell Leukemia Transcription Factor Interacting Protein 1; Hematopoietic PBX-interacting protein
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PBXIP1 is a regulator of pre-B-cell leukemia transcription factors (BPXs) function. It inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. PBXIP1 also tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.
HPIP is mainly localized in the cytosol and in small amounts in the nucleus. The region of PBX that interacts with HPIP includes both the homeodomain and immediate N-terminal flanking sequences. Strikingly, electrophoretic mobility shift assays revealed that HPIP inhibits the ability of PBX-HOX heterodimers to bind to target sequences. Moreover, HPIP strongly inhibits the transactivation activity of E2A-PBX. Together these findings suggest that HPIP is a new regulator of PBX function.
HPIP is mainly localized in the cytosol and in small amounts in the nucleus. The region of PBX that interacts with HPIP includes both the homeodomain and immediate N-terminal flanking sequences. Strikingly, electrophoretic mobility shift assays revealed that HPIP inhibits the ability of PBX-HOX heterodimers to bind to target sequences. Moreover, HPIP strongly inhibits the transactivation activity of E2A-PBX. Together these findings suggest that HPIP is a new regulator of PBX function.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) | ELISA Kit Customized Service Offer |
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