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Laminin Receptor 1 (LAMR1)

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RPSA; LRP; 37LRP; p40; 40S ribosomal protein SA; 37 kDa laminin receptor precursor; Colon carcinoma laminin-binding protein; Multidrug resistance-associated protein MGr1-Ag

Laminin Receptor 1 (LAMR1)
CCC P886
HGNC 6502
MGI 105381
PubMed 14730304
RGD 71026
UniProt P08865
LAMR1 has a heterodimeric structure similar to that of receptors for other extracellular matrix proteins such as the fibronectin and vitronectin receptors. Incorporation of the laminin receptor into lysosomal membranes made it possible for lysosomes to attach to surfaces coated with laminin.The particular patterns were accounted for by the presence of up to 16 and 21 copies of the laminin receptor gene per haploid genome in human and mouse, respectively. Pseudogenes were identified on chromosomes 3, 12, 14, and X. The features suggested that the laminin receptor gene belongs to a retroposon family in mammals.The deduced 295-amino acid protein has a highly negatively charged C-terminal segment and lacks consensus sequences for an N-terminal signal sequence, amphipathic alpha-helices, and N-glycosylation sites.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP886Hu01 Recombinant Laminin Receptor 1 (LAMR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAP886Hu01 Polyclonal Antibody to Laminin Receptor 1 (LAMR1) WB; IHC; ICC; IP.
MAP886Hu21 Monoclonal Antibody to Laminin Receptor 1 (LAMR1) WB; IHC; ICC; IP.
Assay Kits SEP886Hu ELISA Kit for Laminin Receptor 1 (LAMR1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Laminin Receptor 1 (LAMR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Laminin Receptor 1 (LAMR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Laminin Receptor 1 (LAMR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Laminin Receptor 1 (LAMR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Laminin Receptor 1 (LAMR1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Laminin Receptor 1 (LAMR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Laminin Receptor 1 (LAMR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Laminin Receptor 1 (LAMR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Laminin Receptor 1 (LAMR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Laminin Receptor 1 (LAMR1) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP886Po01 Recombinant Laminin Receptor 1 (LAMR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAP886Po01 Polyclonal Antibody to Laminin Receptor 1 (LAMR1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Laminin Receptor 1 (LAMR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Laminin Receptor 1 (LAMR1) ELISA Kit Customized Service Offer
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  2. "Characteristics of a multicopy gene family predominantly consisting of processed pseudogenes."Nucleic Acids Res. 17:3829-3843(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning of 67-kDa laminin receptor cDNA and gene expression in normal and malignant cell lines of the human lung."Cancer Lett. 62:199-203(1992) [PubMed] [Europe PMC] [Abstract]
  4. "Isolation from a multigene family of the active human gene of the metastasis-associated multifunctional protein 37LRP/p40 at chromosome 3p21.3."Oncogene 13:495-503(1996) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. , Submitted (JUL-2004) to UniProtKB
  7. "Determination and analysis of the primary sequence of human laminin-binding protein."Dokl. Biochem. 313:227-231(1990)
  8. "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]
  9. , Submitted (DEC-2008) to UniProtKB
  10. "The gene for human E2 small nucleolar RNA resides in an intron of a laminin-binding protein gene."Genomics 30:400-401(1995) [PubMed] [Europe PMC] [Abstract]
  11. "Altered levels of laminin receptor mRNA in various human carcinoma cells that have different abilities to bind laminin."Proc. Natl. Acad. Sci. U.S.A. 83:7137-7141(1986) [PubMed] [Europe PMC] [Abstract]
  12. "A map of 75 human ribosomal protein genes."Genome Res. 8:509-523(1998) [PubMed] [Europe PMC] [Abstract]
  13. "Laminin receptor on human breast carcinoma cells."Proc. Natl. Acad. Sci. U.S.A. 80:444-448(1983) [PubMed] [Europe PMC] [Abstract]
  14. "Functional domains of the 67-kDa laminin receptor precursor."J. Biol. Chem. 266:20440-20446(1991) [PubMed] [Europe PMC] [Abstract]
  15. "Interaction between the 67 kilodalton metastasis-associated laminin receptor and laminin."Kidney Int. 43:30-37(1993) [PubMed] [Europe PMC] [Abstract]
  16. "The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cells."Nat. Med. 3:1383-1388(1997) [PubMed] [Europe PMC] [Abstract]
  17. "Formation of the 67-kDa laminin receptor by acylation of the precursor."J. Cell. Biochem. 69:244-251(1998) [PubMed] [Europe PMC] [Abstract]
  18. "The 67-kDa laminin receptor originated from a ribosomal protein that acquired a dual function during evolution."Mol. Biol. Evol. 15:1017-1025(1998) [PubMed] [Europe PMC] [Abstract]
  19. "Ribosome-associated protein LBP/p40 binds to S21 protein of 40S ribosome: analysis using a yeast two-hybrid system."Biochem. Biophys. Res. Commun. 256:385-390(1999) [PubMed] [Europe PMC] [Abstract]
  20. "Phage display mapping for peptide 11 sensitive sequences binding to laminin-1."J. Mol. Biol. 298:431-445(2000) [PubMed] [Europe PMC] [Abstract]
  21. "The 37-kDa/67-kDa laminin receptor acts as the cell-surface receptor for the cellular prion protein."EMBO J. 20:5863-5875(2001) [PubMed] [Europe PMC] [Abstract]
  22. "The protein phosphatase-1 targeting subunit TIMAP regulates LAMR1 phosphorylation."Biochem. Biophys. Res. Commun. 338:1327-1334(2005) [PubMed] [Europe PMC] [Abstract]
  23. "67-kDa laminin receptor promotes internalization of cytotoxic necrotizing factor 1-expressing Escherichia coli K1 into human brain microvascular endothelial cells."J. Biol. Chem. 280:1360-1368(2005) [PubMed] [Europe PMC] [Abstract]
  24. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  25. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  26. "Crystal structure of the human laminin receptor precursor."J. Biol. Chem. 283:3002-3005(2008) [PubMed] [Europe PMC] [Abstract]