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V-Rel Reticuloendotheliosis Viral Oncogene Homolog (REL)

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I-Rel; c-Rel; Proto-oncogene c-Rel

V-Rel Reticuloendotheliosis Viral Oncogene Homolog (REL)
CCC P741
HGNC 9954
MGI 97897
PubMed 1577270
RGD 1311231
UniProt Q04864
Wiki REL
The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes RELA, RELB, NFKB1, and NFKB2. These proteins are related through a highly conserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor.Further studies identified protein kinase C-theta (PRKCQ) as a positive regulator of c-Rel transcriptional activity, as well as downstream target genes. In human breast cancer cell lines, there was an inverse correlation between ESR1 and PRKCQ mRNA, and PRKCQ was found to inhibit ESR1 expression via activation of AKT1. PRKCQ plays a pivotal role in mammary tumorigenesis by activating AKT, which ultimately leads to derepression of c-Rel through inhibition of ESR1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant V-Rel Reticuloendotheliosis Viral Oncogene Homolog (REL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to V-Rel Reticuloendotheliosis Viral Oncogene Homolog (REL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to V-Rel Reticuloendotheliosis Viral Oncogene Homolog (REL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for V-Rel Reticuloendotheliosis Viral Oncogene Homolog (REL) CLIA Kit Customized Service Offer
n/a ELISA Kit for V-Rel Reticuloendotheliosis Viral Oncogene Homolog (REL) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP741Mu01 Recombinant V-Rel Reticuloendotheliosis Viral Oncogene Homolog (REL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to V-Rel Reticuloendotheliosis Viral Oncogene Homolog (REL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to V-Rel Reticuloendotheliosis Viral Oncogene Homolog (REL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for V-Rel Reticuloendotheliosis Viral Oncogene Homolog (REL) CLIA Kit Customized Service Offer
n/a ELISA Kit for V-Rel Reticuloendotheliosis Viral Oncogene Homolog (REL) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant V-Rel Reticuloendotheliosis Viral Oncogene Homolog (REL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to V-Rel Reticuloendotheliosis Viral Oncogene Homolog (REL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to V-Rel Reticuloendotheliosis Viral Oncogene Homolog (REL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for V-Rel Reticuloendotheliosis Viral Oncogene Homolog (REL) CLIA Kit Customized Service Offer
n/a ELISA Kit for V-Rel Reticuloendotheliosis Viral Oncogene Homolog (REL) ELISA Kit Customized Service Offer
  1. "A human rel proto-oncogene cDNA containing an Alu fragment as a potential coding exon."Oncogene 4:935-942(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Genetic characterization of human c-rel sequences."Mol. Cell. Biol. 5:2826-2831(1985) [PubMed] [Europe PMC] [Abstract]
  5. "A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene."EMBO J. 11:205-213(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor."Oncogene 9:1487-1492(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Regulation of intercellular adhesion molecule-1 gene by tumor necrosis factor-alpha is mediated by the nuclear factor-kappaB heterodimers p65/p65 and p65/c-Rel in the absence of p50."Cell Growth Differ. 8:335-342(1997) [PubMed] [Europe PMC] [Abstract]
  8. "A new member of the IkappaB protein family, IkappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription."Mol. Cell. Biol. 17:6184-6190(1997) [PubMed] [Europe PMC] [Abstract]
  9. "Tumor necrosis factor-alpha activation of NF-kappa B requires the phosphorylation of Ser-471 in the transactivation domain of c-Rel."J. Biol. Chem. 275:24383-24391(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Leishmania major amastigotes induce p50/c-Rel NF-kappa B transcription factor in human macrophages: involvement in cytokine synthesis."Infect. Immun. 72:2582-2589(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras."Mol. Cell. Biol. 24:3048-3056(2004) [PubMed] [Europe PMC] [Abstract]
  12. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]