Heat Shock 70kDa Protein 12B (HSPA12B)

The deduced proteins contains 685 and 686 amino acids, respectively, and have an atypical HSP70 ATPase domain, which is in 2 parts separated by a spacer region. Mouse and human HSPA12B share 93% amino acid identity, and human HSPA12B shares 60% identity with HSPA12A. Northern blot analysis of human tissues detected highest expression of a 3.5-kb transcript in muscle and heart, with lower expression in liver and kidney. In mouse, expression of Hspa12b was high in heart, but low or absent in all other tissues examined.both Hspa12a and Hspa12b were preferentially expressed in atherosclerotic lesions of mouse aorta. In situ hybridization confirmed that Hspa12a and Hspa12b were expressed in lesions, but not in normal nonlesional aortic tissue.