Sp140 Nuclear Body Protein (SP140)

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LYSP100-B; LYSP100-A; Lymphoid-restricted homolog of Sp100; Nuclear autoantigen Sp-140; Speckled 140 kDa

Sp140 Nuclear Body Protein (SP140)
The N terminus of SP140, between amino acids 29 and 157, is 49% identical to a corresponding N-terminal region of SP100. The C terminus of SP140 contains a cysteine-rich zinc finger motif and a bromodomain. SP140 also has a central nuclear localization signal. RNA dot blot analysis detected high SP140 expression in spleen and peripheral blood leukocytes, with much lower levels in thymus, prostate, ovary, small intestine, and colon; other tissues showed little to no expression. Low expression of a smaller transcript was also observed. Western blot analysis with PBC autoantibodies detected SP140 at an apparent molecular mass of 140 kD following in vitro transcription and translation. Immunohistochemistry demonstrated that SP140 colocalized with PML in dense nuclear bodies in activated myeloid precursor cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN896Hu01 Recombinant Sp140 Nuclear Body Protein (SP140) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAN896Hu01 Polyclonal Antibody to Sp140 Nuclear Body Protein (SP140) WB; IHC; ICC; IP.
MAN896Hu21 Monoclonal Antibody to Sp140 Nuclear Body Protein (SP140) WB; IHC; ICC; IP.
Assay Kits SEN896Hu ELISA Kit for Sp140 Nuclear Body Protein (SP140) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sp140 Nuclear Body Protein (SP140) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sp140 Nuclear Body Protein (SP140) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sp140 Nuclear Body Protein (SP140) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sp140 Nuclear Body Protein (SP140) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sp140 Nuclear Body Protein (SP140) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sp140 Nuclear Body Protein (SP140) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sp140 Nuclear Body Protein (SP140) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sp140 Nuclear Body Protein (SP140) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sp140 Nuclear Body Protein (SP140) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sp140 Nuclear Body Protein (SP140) ELISA Kit Customized Service Offer
  1. "LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies."Blood 88:1423-1426(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and characterization of a leukocyte-specific component of the nuclear body."J. Biol. Chem. 271:29198-29204(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Structure of human Sp140 PHD finger: an atypical fold interacting with Pin1."FEBS J. 281:216-231(2014) [PubMed] [Europe PMC] [Abstract]