Vitexin (Vit)

Vitexin is an apigenin flavone glucoside, a chemical compound found in the passion flower, Vitex agnus-castus (chaste tree or chasteberry), in the Phyllostachys nigra bamboo leaves, in the pearl millet (Pennisetum millet), and in Hawthorn.
Exposure to anoxia or vitexin preconditioning significantly increased the phospho-ERK level, and the increase was markedly inhibited by PD98059, an inhibitor of the upstream kinase of ERK. These results suggest that vitexin preconditioning has a protective effect on cardiomyocytes A/R injury through the improvement of cell viability, decrease of LDH and CK release, such that the protective mechanism may relate to its ability to inhibit the cardiomyocytes apoptosis, reduce the cardiomyocytes calcium overload and increase the abundance of phosphor-ERK1/2 of the cardiomyocytes after anoxia and reoxygenation.