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Myeloid/Lymphoid Or Mixed Lineage Leukemia 5 (MLL5)

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HDCMC04P; KMT2E; Histone-lysine N-methyltransferase 2E

Myeloid/Lymphoid Or Mixed Lineage Leukemia 5 (MLL5)
CCC N732
HGNC 18541
MGI 1924825
PubMed 23629655
UniProt Q8IZD2
MLL5 shares 38% amino acid identity with MLL, but it lacks the A-T hooks and MT homology domains found in MLL. Northern blot analysis detected a 6.5-kb transcript in all hematopoietic tissues examined.
MLL5 expression was also detected in all tissues analyzed on RNA tissue arrays, with the highest levels in fetal thymus and kidney and in adult hematopoietic tissues, jejunum, and cerebellum.MLL5 was biochemically identified in a GlcNAcylation-dependent multisubunit complex associating with nuclear retinoic acid receptor RAR-alpha (RARA), serving as a mono- and dimethyl transferase to H3K4. GlcNAcylation at thr440 in the MLL5 SET domain evoked its H3K4 HKMT activity and coactivated RAR-alpha in target gene promoters.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myeloid/Lymphoid Or Mixed Lineage Leukemia 5 (MLL5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia 5 (MLL5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia 5 (MLL5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia 5 (MLL5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia 5 (MLL5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myeloid/Lymphoid Or Mixed Lineage Leukemia 5 (MLL5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia 5 (MLL5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myeloid/Lymphoid Or Mixed Lineage Leukemia 5 (MLL5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia 5 (MLL5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myeloid/Lymphoid Or Mixed Lineage Leukemia 5 (MLL5) ELISA Kit Customized Service Offer
  1. "MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia."Oncogene 21:4849-4854(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of a cellular ligand for the natural cytotoxicity receptor NKp44."Blood 122:2935-2942(2013) [PubMed] [Europe PMC] [Abstract]
  3. "Identification and characterization of a novel gene located in the commonly deleted region 7q22-q31.1 in myeloid leukemias."Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases and Peripheral blood leukocyte.
  4. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract], Liver and Uterus.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression."Proc. Natl. Acad. Sci. U.S.A. 101:757-762(2004) [PubMed] [Europe PMC] [Abstract]
  8. "RNA interference against mixed lineage leukemia 5 resulted in cell cycle arrest."Int. J. Biochem. Cell Biol. 40:2472-2481(2008) [PubMed] [Europe PMC] [Abstract]
  9. "GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis."Nature 459:455-459(2009) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]