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Minichromosome Maintenance Complex Binding Protein (MCMBP)

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MCM-BP; C10orf119; Mini-chromosome maintenance complex-binding protein

Minichromosome Maintenance Complex Binding Protein (MCMBP)
CCC N325
HGNC 25782
MGI 1920977
PubMed 23322785
RGD 1306730
UniProt Q9BTE3
MCMBP bound to chromatin in a manner typical of MCM proteins, and that MCMBP was preferentially associated with a cellular origin in G1 but not S phase. In vivo tagging experiments, coimmunoprecipitation of endogenous MCM proteins in HeLa cells, and analysis of recombinant MCM complexes in insect cells revealed that MCMBP formed a hexamer with MCM3 through MCM7 that excluded MCM2; conversely, the hexamer of MCM2 through MCM7 excluded MCMBP. MCMBP also formed a complex with the MCM4 /MCM6/MCM7 core helicase in vitro, but, unlike MCM2, MCMBP did not inhibit helicase activity. The 640-amino acid MCMBP protein shares limited homology with members of the MCM family and is highly conserved in multicellular eukaryotes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Minichromosome Maintenance Complex Binding Protein (MCMBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Minichromosome Maintenance Complex Binding Protein (MCMBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Minichromosome Maintenance Complex Binding Protein (MCMBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Minichromosome Maintenance Complex Binding Protein (MCMBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Minichromosome Maintenance Complex Binding Protein (MCMBP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Minichromosome Maintenance Complex Binding Protein (MCMBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Minichromosome Maintenance Complex Binding Protein (MCMBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Minichromosome Maintenance Complex Binding Protein (MCMBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Minichromosome Maintenance Complex Binding Protein (MCMBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Minichromosome Maintenance Complex Binding Protein (MCMBP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Minichromosome Maintenance Complex Binding Protein (MCMBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Minichromosome Maintenance Complex Binding Protein (MCMBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Minichromosome Maintenance Complex Binding Protein (MCMBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Minichromosome Maintenance Complex Binding Protein (MCMBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Minichromosome Maintenance Complex Binding Protein (MCMBP) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification and characterization of a novel component of the human minichromosome maintenance complex."Mol. Cell. Biol. 27:3044-3055(2007) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of proteins that may directly interact with human RPA."J. Biochem. 148:539-547(2010) [PubMed] [Europe PMC] [Abstract]
  9. "The MCM-binding protein ETG1 aids sister chromatid cohesion required for postreplicative homologous recombination repair."PLoS Genet. 6:E1000817-E1000817(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "MCM-BP regulates unloading of the MCM2-7 helicase in late S phase."Genes Dev. 25:165-175(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]