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Nei Endonuclease VIII Like Protein 3 (NEIL3)

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FPG2; hFPG2; hNEI3; Endonuclease 8-like 3; DNA glycosylase FPG2; DNA glycosylase/AP lyase Neil3; Nei-like protein 3

Nei Endonuclease VIII Like Protein 3 (NEIL3)
CCC N291
HGNC 24573
MGI 2384588
PubMed 23755964
RGD 1310562
UniProt Q8TAT5
Wiki NEIL3
NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction.
The deduced 605-amino acid protein has a calculated molecular mass of 67.9 kD. Unlike NEIL1, NEIL3 contains a RAN-binding protein-like zinc finger motif and C-terminal zinc ribbon domains. Northern blot analysis of several human tissues detected a 2.4-kb transcript only in testis and thymus. Fluorescence-tagged NEIL3 colocalized with RPA2 in the nuclei of transfected HeLa cells and was excluded from nucleoli.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nei Endonuclease VIII Like Protein 3 (NEIL3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nei Endonuclease VIII Like Protein 3 (NEIL3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nei Endonuclease VIII Like Protein 3 (NEIL3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nei Endonuclease VIII Like Protein 3 (NEIL3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nei Endonuclease VIII Like Protein 3 (NEIL3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN291Mu01 Recombinant Nei Endonuclease VIII Like Protein 3 (NEIL3) Positive Control; Immunogen; SDS-PAGE; WB.
RPN291Mu02 Recombinant Nei Endonuclease VIII Like Protein 3 (NEIL3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAN291Mu01 Polyclonal Antibody to Nei Endonuclease VIII Like Protein 3 (NEIL3) WB; IHC; ICC; IP.
PAN291Mu02 Polyclonal Antibody to Nei Endonuclease VIII Like Protein 3 (NEIL3) WB; IHC; ICC; IP.
Assay Kits SEN291Mu ELISA Kit for Nei Endonuclease VIII Like Protein 3 (NEIL3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nei Endonuclease VIII Like Protein 3 (NEIL3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nei Endonuclease VIII Like Protein 3 (NEIL3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nei Endonuclease VIII Like Protein 3 (NEIL3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nei Endonuclease VIII Like Protein 3 (NEIL3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nei Endonuclease VIII Like Protein 3 (NEIL3) ELISA Kit Customized Service Offer
  1. "A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue."J. Biol. Chem. 277:42205-42213(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA."Nucleic Acids Res. 30:4926-4936(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Hematopoietic tissue-specific expression of mouse Neil3 for endonuclease VIII-like protein."J. Biochem. 138:763-772(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Expression patterns of Neil3 during embryonic brain development and neoplasia."BMC Neurosci. 10:45-45(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Human Nei-like protein NEIL3 has AP lyase activity specific for single-stranded DNA and confers oxidative stress resistance in Escherichia coli mutant."Genes Cells 14:261-270(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Expression and purification of NEIL3, a human DNA glycosylase homolog."Protein Expr. Purif. 65:160-164(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Release from quiescence stimulates the expression of human NEIL3 under the control of the Ras dependent ERK-MAP kinase pathway."DNA Repair 11:401-409(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Expression and purification of active mouse and human NEIL3 proteins."Protein Expr. Purif. 84:130-139(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin."DNA Repair 12:1159-1164(2013) [PubMed] [Europe PMC] [Abstract]