DFNB59 consists of 7 exons spanning 9.8 kb of genomic sequence. Exon organization between the pejvakin and DFNA5 genes throughout the region of similarity is identical, indicating that these 2 genes share a common origin.The 352-amino acid pejvakin protein shares significant similarity with the DFNA5 protein in the respective N-terminal regions, with 32% identity over a stretch of 250 amino acids.
The pejvakin sequence contains a nuclear localization signal (residues 249-258) and a zinc-binding motif (residues 305-331). Pejvakin belongs to a family of proteins, including DFNA5 and the gasdermins, found only in vertebrates. Immunohistofluorescence microscopy detected pejvakin in the cell bodies of neurons of the afferent auditory pathway.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Pejvakin (PJVK) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Pejvakin (PJVK) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Pejvakin (PJVK) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Pejvakin (PJVK) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Pejvakin (PJVK) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Pejvakin (PJVK) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Pejvakin (PJVK) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Pejvakin (PJVK) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Pejvakin (PJVK) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Pejvakin (PJVK) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Pejvakin (PJVK) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Pejvakin (PJVK) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Pejvakin (PJVK) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Pejvakin (PJVK) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Pejvakin (PJVK) | ELISA Kit Customized Service Offer |
- "Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy."Nat. Genet. 38:770-778(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "A p.C343S missense mutation in PJVK causes progressive hearing loss."Gene 504:98-101(2012) [PubMed] [Europe PMC] [Abstract]