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Parathyroid Hormone 2 (PTH2)

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TIP39; TIPF39; Tuberoinfundibular 39 Residues; Tuberoinfundibular peptide of 39 residues

Parathyroid Hormone 2 (PTH2)
CCC M752
HGNC 30828
MGI 2152297
PubMed 12529938
RGD 1559447
UniProt Q96A98
TIP39 is related to parathyroid hormone (PTH) and PTH-related protein (PTHRP) and is a ligand for PTH receptor-2 (PTHR2). The deduced 100-amino acid mouse precursor protein shares 78% identity with the human precursor, and the secreted peptides share 97% identity. Northern blot analysis of mouse tissues detected a 4.5-kb Tip39 transcript expressed at a high level in testis and at low levels in liver, kidney, and possibly heart. In situ hybridization detected mouse Tip39 mRNA in epithelium of seminiferous tubules and in several brain regions, including nucleus ruber, nucleus centralis pontis, and nucleus subparafascicularis thalami. Phylogenic analysis suggested that TIP39, PTH, and PTHRP may have evolved from a common ancestor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Parathyroid Hormone 2 (PTH2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Parathyroid Hormone 2 (PTH2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Parathyroid Hormone 2 (PTH2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Parathyroid Hormone 2 (PTH2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Parathyroid Hormone 2 (PTH2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Parathyroid Hormone 2 (PTH2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Parathyroid Hormone 2 (PTH2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Parathyroid Hormone 2 (PTH2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Parathyroid Hormone 2 (PTH2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Parathyroid Hormone 2 (PTH2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Parathyroid Hormone 2 (PTH2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Parathyroid Hormone 2 (PTH2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Parathyroid Hormone 2 (PTH2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Parathyroid Hormone 2 (PTH2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Parathyroid Hormone 2 (PTH2) ELISA Kit Customized Service Offer
  1. "Characterization of the human and mouse genes encoding the tuberoinfundibular peptide of 39 residues, a ligand of the parathyroid hormone receptor family."J. Endocrinol. 174:95-102(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception."Proc. Natl. Acad. Sci. U.S.A. 99:1651-1656(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Tuberoinfundibular peptide of 39 residues (TIP39): molecular structure and activity for parathyroid hormone 2 receptor."Neuropharmacology 44:141-153(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues."Endocrinology 143:1047-1057(2002) [PubMed] [Europe PMC] [Abstract]
  6. "PTH2 receptor-mediated inhibitory effect of parathyroid hormone and TIP39 on cell proliferation."Eur. J. Pharmacol. 468:159-166(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization."Mol. Endocrinol. 18:1486-1498(2004) [PubMed] [Europe PMC] [Abstract]