IGF Like Family, Member 2 (IGFL2)

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Insulin growth factor-like family member 2

IGF Like Family, Member 2 (IGFL2)
IGFL2 belongs to the insulin-like growth factor (IGF) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth .By EST database analysis and DNA sequence assembly, Emtage et al. (2006) identified 4 members of a human gene family, which they designated IGF-like (IGFL), encoding small secreted proteins.IGFL2 encodes a deduced 95-amino acid protein with a signal peptide followed by a conserved region with 11 regularly spaced cysteine residues, including 2 CC motifs. Real-time PCR detected IGFL2 in cerebellum, heart, placenta, spleen, stomach, testis, and thymus. Emtage et al. (2006) identified only 1 Igfl sequence in mouse, which cannot be assigned direct orthology with any of the human IGFL sequences.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant IGF Like Family, Member 2 (IGFL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to IGF Like Family, Member 2 (IGFL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to IGF Like Family, Member 2 (IGFL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for IGF Like Family, Member 2 (IGFL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for IGF Like Family, Member 2 (IGFL2) ELISA Kit Customized Service Offer
  1. "IGFL: a secreted family with conserved cysteine residues and similarities to the IGF superfamily."Genomics 88:513-520(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Murine IGFL and human IGFL1 are induced in inflammatory skin conditions and bind to a novel TNF receptor family member, IGFLR1."J. Biol. Chem. 286:18969-18981(2011) [PubMed] [Europe PMC] [Abstract]