Hydrocephalus Inducing Protein 2 (HYDIN2)

HYDIN2 gene contains 79 exons and spans approximately 360 kb. It lacks the first 5 exons and last 2 exons of the HYDIN gene. RT-PCR ELISA detected moderate HYDIN2 expression in adult and fetal brain, spinal cord, and all specific brain regions examined. Lower expression was detected in lung, kidney, testis, and ovary, and little to no expression was detected in other tissues examined.

Database and sequence analyses revealed HYDIN transcripts that had been isolated from lung, testis, NT2 neuronal precursor cells, and Jurkat leukemic T cells, whereas HYDIN2 transcripts had been isolated from brain and NT2 cells only. Both genes appeared to be expressed as alternatively spliced transcripts.