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Tolloid Like Protein 1 (TLL1)

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Tolloid Like Protein 1 (TLL1)
CCC M373
HGNC 11843
MGI 106923
PubMed 10516436
UniProt O43897
Wiki TLL1
TLL1 encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. A similar protein in mice is required during heart development and specifically processes procollagen C-propeptides and chordin at similar cleavage sites. As previously demonstrated for BMP1 and TLD, TLL1 specifically processes procollagen C-propeptides at the physiologically relevant site, whereas TLL2 lacks this activity. BMP1 and TLL1 cleave chordin, at sites similar to procollagen C-propeptide cleavage sites, and counteract dorsalizing effects of chordin upon overexpression on Xenopus embryos. Proteases TLD and TLL2 do not cleave chordin.TLL1 gene plays multiple roles in formation of the mammalian heart and is essential for formation of the interventricular septum.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM373Hu01 Recombinant Tolloid Like Protein 1 (TLL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM373Hu01 Polyclonal Antibody to Tolloid Like Protein 1 (TLL1) WB; IHC; ICC; IP.
MAM373Hu21 Monoclonal Antibody to Tolloid Like Protein 1 (TLL1) WB; IHC; ICC; IP.
Assay Kits SEM373Hu ELISA Kit for Tolloid Like Protein 1 (TLL1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tolloid Like Protein 1 (TLL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tolloid Like Protein 1 (TLL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tolloid Like Protein 1 (TLL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tolloid Like Protein 1 (TLL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tolloid Like Protein 1 (TLL1) ELISA Kit Customized Service Offer
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis."Dev. Biol. 213:283-300(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Bone morphogenetic protein-1 processes probiglycan."J. Biol. Chem. 275:30504-30511(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures."J. Biol. Chem. 276:22537-22543(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases."J. Mol. Biol. 384:228-239(2008) [PubMed] [Europe PMC] [Abstract]
  6. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in mammalian tolloid-like 1 gene detected in adult patients with ASD."Eur. J. Hum. Genet. 17:344-351(2009) [PubMed] [Europe PMC] [Abstract]