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Tax1 Binding Protein 1 (TAX1BP1)

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CALCOCO3; T6BP; TXBP151; TRAF6-binding protein

Tax1 Binding Protein 1 (TAX1BP1)
CCC M342
HGNC 11575
MGI 1289308
PubMed 18239685
RGD 708579
UniProt Q86VP1
Wiki TAX1BP1
TAX1BP1 binds TRAF6 but not TRAFs 1-5; the interaction requires the N-terminal zinc and ring finger domains of TRAF6 and either the N-terminal first coiled-coil region or the 2 coiled-coil regions of the C-terminus of TAX1BP1. Immunoprecipitation and immunoblot analysis determined that stimulation of cells with IL1B, but not with TNF or CD40LG, induces independent, mutually exclusive TRAF6/TAX1BP1 complexes as well as TRAF6/IRAK complexes. Transient expression of TRAF6, but not TAX1BP1, induces NFKB and JNK (MAPK8) activation.TXBP151, encoding a 747-amino acid protein. Northern blot analysis revealed expression of 1.9- and 2.4-kb transcripts in various cell lines. Western blot analysis showed that TAX1BP1 is expressed as an 86-kD or a 68-kD protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tax1 Binding Protein 1 (TAX1BP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tax1 Binding Protein 1 (TAX1BP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tax1 Binding Protein 1 (TAX1BP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tax1 Binding Protein 1 (TAX1BP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tax1 Binding Protein 1 (TAX1BP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tax1 Binding Protein 1 (TAX1BP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tax1 Binding Protein 1 (TAX1BP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tax1 Binding Protein 1 (TAX1BP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tax1 Binding Protein 1 (TAX1BP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tax1 Binding Protein 1 (TAX1BP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tax1 Binding Protein 1 (TAX1BP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tax1 Binding Protein 1 (TAX1BP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tax1 Binding Protein 1 (TAX1BP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tax1 Binding Protein 1 (TAX1BP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tax1 Binding Protein 1 (TAX1BP1) ELISA Kit Customized Service Offer
  1. "The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases."Oncogene 18:4182-4190(1999) [PubMed] [Europe PMC] [Abstract]
  2. "T6BP, a TRAF6-interacting protein involved in IL-1 signaling."Proc. Natl. Acad. Sci. U.S.A. 97:9567-9572(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins."Biochem. Biophys. Res. Commun. 313:654-665(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Protein profile of tax-associated complexes."J. Biol. Chem. 279:495-508(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "The structure of TAX1BP1 UBZ1+2 provides insight into target specificity and adaptability."J. Mol. Biol. 426:674-690(2014) [PubMed] [Europe PMC] [Abstract]
  13. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  14. "The kinase IKKalpha inhibits activation of the transcription factor NF-kappaB by phosphorylating the regulatory molecule TAX1BP1."Nat. Immunol. 12:834-843(2011) [PubMed] [Europe PMC] [Abstract]