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Speckle Type POZ Protein (SPOP)

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TEF2; HIB homolog 1; Roadkill homolog 1

Speckle Type POZ Protein (SPOP)
CCC M278
HGNC 11254
MGI 1343085
PubMed 23559371
RGD 1311613
UniProt O43791
SPOP encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.The SPOP gene encodes a 374-amino acid polypeptide that contains a poxvirus and zinc finger (POZ) domain and an evolutionarily conserved N-terminal region.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Speckle Type POZ Protein (SPOP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Speckle Type POZ Protein (SPOP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Speckle Type POZ Protein (SPOP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Speckle Type POZ Protein (SPOP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Speckle Type POZ Protein (SPOP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Speckle Type POZ Protein (SPOP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Speckle Type POZ Protein (SPOP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Speckle Type POZ Protein (SPOP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Speckle Type POZ Protein (SPOP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Speckle Type POZ Protein (SPOP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Speckle Type POZ Protein (SPOP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Speckle Type POZ Protein (SPOP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Speckle Type POZ Protein (SPOP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Speckle Type POZ Protein (SPOP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Speckle Type POZ Protein (SPOP) ELISA Kit Customized Service Offer
  1. "Identification of a novel nuclear speckle-type protein, SPOP."FEBS Lett. 418:23-26(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases."Nat. Cell Biol. 5:1001-1007(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Daxx-mediated transcriptional repression of MMP1 gene is reversed by SPOP."Biochem. Biophys. Res. Commun. 320:760-765(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase."Proc. Natl. Acad. Sci. U.S.A. 102:7635-7640(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus."Development 133:2001-2010(2006) [PubMed] [Europe PMC] [Abstract]
  8. "A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor."Dev. Cell 10:719-729(2006) [PubMed] [Europe PMC] [Abstract]
  9. "BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase."J. Biol. Chem. 281:12664-12672(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Breast cancer metastasis suppressor 1 (BRMS1) is destabilized by the Cul3-SPOP E3 ubiquitin ligase complex."Biochem. Biophys. Res. Commun. 415:720-726(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Solution structure of N-terminal domain of speckle-type POZ protein."Submitted (NOV-2005) to the PDB data bank
  12. "Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases."Mol. Cell 36:39-50(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase."Structure 20:1141-1153(2012) [PubMed] [Europe PMC] [Abstract]