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Recombination Signal Binding Protein For Immunoglobulin Kappa J Region (RBPJ)

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CBF1; IGKJRB1; KBF2; RBP-J; RBPJK; RBPSUH; SUH; Csl; Suppressor Of Hairless Homolog; J kappa-recombination signal-binding protein; Renal carcinoma antigen NY-REN-30

Recombination Signal Binding Protein For Immunoglobulin Kappa J Region (RBPJ)
CCC M110
HGNC 5724
MGI 96522
PubMed 23958593
RGD 1593096
UniProt Q06330
Wiki RBPJ
RBPJ is a human homolog for the Drosophila gene Suppressor of Hairless. It is classically used as a promoter region to demonstrate Notch1 signaling.The Igkjrb protein, identified in nuclear extracts from a mouse pre-B-cell line as a binding protein specific to Jk-type RS, may also be involved. The IGKJRB gene is well conserved among many species such as human, mouse, Xenopus, and Drosophila. Three types of cDNA with different 5-prime sequences were isolated, suggesting the presence of 3 protein isoforms. Two of these may be specific to human cells because the mouse counterparts were not detected. The amino acid sequences of the human and mouse genes are 98% identical in exons 2 through 11, whereas the homology of the human and mouse exon 1 sequences were 75%.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Recombination Signal Binding Protein For Immunoglobulin Kappa J Region (RBPJ) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Recombination Signal Binding Protein For Immunoglobulin Kappa J Region (RBPJ) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Recombination Signal Binding Protein For Immunoglobulin Kappa J Region (RBPJ) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Recombination Signal Binding Protein For Immunoglobulin Kappa J Region (RBPJ) CLIA Kit Customized Service Offer
n/a ELISA Kit for Recombination Signal Binding Protein For Immunoglobulin Kappa J Region (RBPJ) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Recombination Signal Binding Protein For Immunoglobulin Kappa J Region (RBPJ) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Recombination Signal Binding Protein For Immunoglobulin Kappa J Region (RBPJ) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Recombination Signal Binding Protein For Immunoglobulin Kappa J Region (RBPJ) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Recombination Signal Binding Protein For Immunoglobulin Kappa J Region (RBPJ) CLIA Kit Customized Service Offer
n/a ELISA Kit for Recombination Signal Binding Protein For Immunoglobulin Kappa J Region (RBPJ) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Recombination Signal Binding Protein For Immunoglobulin Kappa J Region (RBPJ) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Recombination Signal Binding Protein For Immunoglobulin Kappa J Region (RBPJ) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Recombination Signal Binding Protein For Immunoglobulin Kappa J Region (RBPJ) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Recombination Signal Binding Protein For Immunoglobulin Kappa J Region (RBPJ) CLIA Kit Customized Service Offer
n/a ELISA Kit for Recombination Signal Binding Protein For Immunoglobulin Kappa J Region (RBPJ) ELISA Kit Customized Service Offer
  1. "Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue."Genomics 17:306-315(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappa."Science 265:92-95(1994) [PubMed] [Europe PMC] [Abstract]
  6. "The amino-terminal domains of Epstein-Barr virus nuclear proteins 3A, 3B, and 3C interact with RBPJ(kappa)."J. Virol. 70:3068-3074(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Antigens recognized by autologous antibody in patients with renal-cell carcinoma."Int. J. Cancer 83:456-464(1999) [PubMed] [Europe PMC] [Abstract]
  8. "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex."Proc. Natl. Acad. Sci. U.S.A. 96:23-28(1999) [PubMed] [Europe PMC] [Abstract]
  9. "A role for SKIP in EBNA2 activation of CBF1-repressed promoters."J. Virol. 74:1939-1947(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Intracellular forms of human NOTCH1 interact at distinctly different levels with RBP-jkappa in human B and T cells."Leukemia 14:84-92(2000) [PubMed] [Europe PMC] [Abstract]
  11. "SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway."EMBO J. 21:5417-5426(2002) [PubMed] [Europe PMC] [Abstract]
  12. "RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J."EMBO J. 30:43-56(2011) [PubMed] [Europe PMC] [Abstract]
  13. "A SILAC-based screen for Methyl-CpG binding proteins identifies RBP-J as a DNA methylation and sequence-specific binding protein."PLoS ONE 6:E25884-E25884(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2."Nucleic Acids Res. 41:2255-2266(2013) [PubMed] [Europe PMC] [Abstract]
  15. "Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes."Cell 124:973-983(2006) [PubMed] [Europe PMC] [Abstract]
  16. "RBPJ mutations identified in two families affected by Adams-Oliver syndrome."Am. J. Hum. Genet. 91:391-395(2012) [PubMed] [Europe PMC] [Abstract]