Period Circadian Protein 1 (PER1)

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PER; RIGUI; hPER; Circadian clock protein PERIOD 1; Circadian pacemaker protein Rigui

Period Circadian Protein 1 (PER1)

PER1 is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. Alternative splicing has been observed in this gene; however, these variants have not been fully described.Widely expressed. Found in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, kidney, spleen, thymus, prostate, testis, ovary and small intestine. Highest level in skeletal muscle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM012Hu01 Recombinant Period Circadian Protein 1 (PER1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM012Hu01 Polyclonal Antibody to Period Circadian Protein 1 (PER1) WB; IHC; ICC; IP.
MAM012Hu21 Monoclonal Antibody to Period Circadian Protein 1 (PER1) WB; IHC; ICC; IP.
Assay Kits SEM012Hu ELISA Kit for Period Circadian Protein 1 (PER1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Period Circadian Protein 1 (PER1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Period Circadian Protein 1 (PER1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Period Circadian Protein 1 (PER1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Period Circadian Protein 1 (PER1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Period Circadian Protein 1 (PER1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Period Circadian Protein 1 (PER1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Period Circadian Protein 1 (PER1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Period Circadian Protein 1 (PER1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Period Circadian Protein 1 (PER1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Period Circadian Protein 1 (PER1) ELISA Kit Customized Service Offer
  1. "Rigui, a putative mammalian ortholog of the Drosophila period gene."Cell 90:1003-1011(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Circadian oscillation of a mammalian homologue of the Drosophila period gene."Nature 389:512-516(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The human Per1 gene: genomic organization and promoter analysis of the first human orthologue of the Drosophila period gene."Gene 253:161-170(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The human and mouse Period1 genes: five well-conserved E-boxes additively contribute to the enhancement of mPer1 transcription."Genomics 65:224-233(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei."Neuron 19:1261-1269(1997) [PubMed] [Europe PMC] [Abstract]
  10. "Phosphorylation and destabilization of human period I clock protein by human casein kinase I epsilon."NeuroReport 11:951-955(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2."FEBS Lett. 489:159-165(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts."Biochem. J. 380:95-103(2004) [PubMed] [Europe PMC] [Abstract]
  13. "SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein."J. Biol. Chem. 280:26863-26872(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  15. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  16. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Metabolism and the circadian clock converge."Physiol. Rev. 93:107-135(2013) [PubMed] [Europe PMC] [Abstract]
  21. "A meeting of two chronobiological systems: circadian proteins Period1 and BMAL1 modulate the human hair cycle clock."J. Invest. Dermatol. 134:610-619(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Molecular architecture of the mammalian circadian clock."Trends Cell Biol. 24:90-99(2014) [PubMed] [Europe PMC] [Abstract]
  23. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]