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PDGFA Associated Protein 1 (PDAP1)

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PAP; PAP1; HASPP28; 28 kDa Heat And Acid Stable Phosphoprotein; PDGF-associated protein

PDGFA Associated Protein 1 (PDAP1)
CCC L999
HGNC 14634
MGI 2448536
PubMed 8780057
RGD 620442
UniProt Q13442
Wiki PDAP1
By screening a retina cDNA library with rat PAP sequence as probe, Fischer and Schubert (1996) cloned the human homolog, designated PDAP1, encoding a deduced 181-amino acid protein. The authors found no obvious secretion signal peptide. Northern blot analysis of newborn rat tissues detected expression in all tissues tested except liver; abundant expression was found in brain.
Fischer and Schubert (1996) found that PDAP1 enhanced PDGFA (173430)-stimulated cell growth in mouse fibroblasts, but inhibited the mitogenic effect of PDGFB (190040). It had no effect on the action of any other growth hormone tested. Solid-phase binding studies showed that the binding between PDGFA and PDAP1 is a low affinity/high capacity interaction.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PDGFA Associated Protein 1 (PDAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PDGFA Associated Protein 1 (PDAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PDGFA Associated Protein 1 (PDAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PDGFA Associated Protein 1 (PDAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for PDGFA Associated Protein 1 (PDAP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PDGFA Associated Protein 1 (PDAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PDGFA Associated Protein 1 (PDAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PDGFA Associated Protein 1 (PDAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PDGFA Associated Protein 1 (PDAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for PDGFA Associated Protein 1 (PDAP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PDGFA Associated Protein 1 (PDAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PDGFA Associated Protein 1 (PDAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PDGFA Associated Protein 1 (PDAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PDGFA Associated Protein 1 (PDAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for PDGFA Associated Protein 1 (PDAP1) ELISA Kit Customized Service Offer
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  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line."Electrophoresis 28:2027-2034(2007) [PubMed] [Europe PMC] [Abstract]
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  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]