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Nuclear Factor, Erythroid Derived 2 Like Protein 2 (NFE2L2)

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NRF2; HEBP1; NF-E2-Related Factor 2; Nuclear factor, erythroid derived 2, like 2

Nuclear Factor, Erythroid Derived 2 Like Protein 2 (NFE2L2)
CCC L947
HGNC 7782
MGI 108420
PubMed 21107315
RGD 620360
UniProt Q16236
Wiki NFE2L2
Nrf2 is a master regulator of the antioxidant response. The antioxidant response is important for the amelioration of oxidative stress. Oxidative stress can result in cancer, cardiovascular diseases, inflammation, neurological diseases, and renal disease. Because Nrf2 is able to induce genes important in combating oxidative stress, thereby activating the body’s own protective response, it is able to protect from a variety of [oxidative stress]-related complications , even in situations where the administration of exogenous antioxidants have failed.NFE2, NFE2L1, and NFE2L2 comprise a family of human genes encoding basic leucine zipper (bZIP) transcription factors. They share highly conserved regions that are distinct from other bZIP families, such as JUN and FOS, although remaining regions have diverged considerably from each other.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL947Hu01 Recombinant Nuclear Factor, Erythroid Derived 2 Like Protein 2 (NFE2L2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAL947Hu21 Monoclonal Antibody to Nuclear Factor, Erythroid Derived 2 Like Protein 2 (NFE2L2) WB; IHC; ICC; IP.
PAL947Hu01 Polyclonal Antibody to Nuclear Factor, Erythroid Derived 2 Like Protein 2 (NFE2L2) WB; IHC; ICC; IP.
Assay Kits SEL947Hu ELISA Kit for Nuclear Factor, Erythroid Derived 2 Like Protein 2 (NFE2L2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL947Mu01 Recombinant Nuclear Factor, Erythroid Derived 2 Like Protein 2 (NFE2L2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL947Mu01 Polyclonal Antibody to Nuclear Factor, Erythroid Derived 2 Like Protein 2 (NFE2L2) WB; IHC; ICC; IP.
Assay Kits SEL947Mu ELISA Kit for Nuclear Factor, Erythroid Derived 2 Like Protein 2 (NFE2L2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL947Ra01 Recombinant Nuclear Factor, Erythroid Derived 2 Like Protein 2 (NFE2L2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAL947Ra21 Monoclonal Antibody to Nuclear Factor, Erythroid Derived 2 Like Protein 2 (NFE2L2) WB; IHC; ICC; IP.
PAL947Ra01 Polyclonal Antibody to Nuclear Factor, Erythroid Derived 2 Like Protein 2 (NFE2L2) WB; IHC; ICC; IP.
Assay Kits SEL947Ra ELISA Kit for Nuclear Factor, Erythroid Derived 2 Like Protein 2 (NFE2L2) Enzyme-linked immunosorbent assay for Antigen Detection.
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  12. "Transformation of eEF1Bdelta into heat-shock response transcription factor by alternative splicing."EMBO Rep. 12:673-681(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization."J. Biol. Chem. 286:7629-7640(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling."EMBO J. 25:3605-3617(2006) [PubMed] [Europe PMC] [Abstract]