≡

Insulin Like Growth Factor 2 mRNA Binding Protein 2 (IGF2BP2)

[Edit]

p62; IMP-2; IMP2; VICKZ2; IGF II mRNA Binding Protein 2; Hepatocellular carcinoma autoantigen p62; VICKZ family member 2

Insulin Like Growth Factor 2 mRNA Binding Protein 2 (IGF2BP2)
CCC L616
HGNC 28867
MGI 1890358
PubMed 22427968
RGD 1305614
UniProt Q9Y6M1
Wiki IGF2BP2
IGF2BP2 encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains several four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
The deduced 598-amino acid protein has a calculated molecular mass of 66 kD. IMP2 contains 6 characteristic RNA-binding modules, including 2 N-terminal RRM domains and 4 central and C-terminal KH domains. It shares 59% amino acid identity with IMP1 and IMP3. The deduced 556-amino acid protein has a calculated molecular mass of 62 kD.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL616Hu01 Recombinant Insulin Like Growth Factor 2 mRNA Binding Protein 2 (IGF2BP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL616Hu01 Polyclonal Antibody to Insulin Like Growth Factor 2 mRNA Binding Protein 2 (IGF2BP2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Insulin Like Growth Factor 2 mRNA Binding Protein 2 (IGF2BP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Like Growth Factor 2 mRNA Binding Protein 2 (IGF2BP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL616Mu01 Recombinant Insulin Like Growth Factor 2 mRNA Binding Protein 2 (IGF2BP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL616Mu01 Polyclonal Antibody to Insulin Like Growth Factor 2 mRNA Binding Protein 2 (IGF2BP2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Insulin Like Growth Factor 2 mRNA Binding Protein 2 (IGF2BP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Like Growth Factor 2 mRNA Binding Protein 2 (IGF2BP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Insulin Like Growth Factor 2 mRNA Binding Protein 2 (IGF2BP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Insulin Like Growth Factor 2 mRNA Binding Protein 2 (IGF2BP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Insulin Like Growth Factor 2 mRNA Binding Protein 2 (IGF2BP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Insulin Like Growth Factor 2 mRNA Binding Protein 2 (IGF2BP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Like Growth Factor 2 mRNA Binding Protein 2 (IGF2BP2) ELISA Kit Customized Service Offer
  1. "A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma."J. Exp. Med. 189:1101-1110(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development."Mol. Cell. Biol. 19:1262-1270(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D)."Biol. Chem. 384:25-37(2003) [PubMed] [Europe PMC] [Abstract]
  6. "VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins."Biol. Cell 97:87-96(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer."Reproduction 130:203-212(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Molecular composition of IMP1 ribonucleoprotein granules."Mol. Cell. Proteomics 6:798-811(2007) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "ZBP1 recognition of beta-actin zipcode induces RNA looping."Genes Dev. 24:148-158(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Two isoforms of the mRNA binding protein IGF2BP2 are generated by alternative translational initiation."PLoS ONE 7:E33140-E33140(2012) [PubMed] [Europe PMC] [Abstract]
  16. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  17. "Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains."Biol. Chem. 394:1077-1090(2013) [PubMed] [Europe PMC] [Abstract]
  18. "Solution structure of the RNA binding domain of IGF-II mRNA-binding protein 2."Submitted (NOV-2005) to the PDB data bank