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Growth Arrest And DNA Damage Inducible Protein Gamma (GADD45g)

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CR6; DDIT2; GADD45gamma; GRP17; Gadd-Related Protein,17 kD; Cytokine-responsive protein CR6; DNA damage-inducible transcript 2 protein

Growth Arrest And DNA Damage Inducible Protein Gamma (GADD45g)
CCC L536
HGNC 4097
MGI 1346325
PubMed 23516551
RGD 1311796
UniProt O95257
Wiki GADD45G
GADD45g is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase.
The GADD45G is highly expressed in placenta.The deduced GADD45G protein contains 159 amino acids. GADD45A, GADD45B, and GADD45G share 55 to 58% amino acid identity. These proteins activated MTK1 kinase activity, both in vivo and in vitro. All 3 GADD45-like genes were induced by environmental stresses, including methyl methanesulfonate, UV, and gamma irradiation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL536Hu01 Recombinant Growth Arrest And DNA Damage Inducible Protein Gamma (GADD45g) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Gamma (GADD45g) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Gamma (GADD45g) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Growth Arrest And DNA Damage Inducible Protein Gamma (GADD45g) CLIA Kit Customized Service Offer
n/a ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Gamma (GADD45g) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL536Mu01 Recombinant Growth Arrest And DNA Damage Inducible Protein Gamma (GADD45g) Positive Control; Immunogen; SDS-PAGE; WB.
RPL536Mu02 Recombinant Growth Arrest And DNA Damage Inducible Protein Gamma (GADD45g) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL536Mu01 Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Gamma (GADD45g) WB; IHC; ICC; IP.
PAL536Mu02 Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Gamma (GADD45g) WB; IHC; ICC; IP.
Assay Kits SEL536Mu ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Gamma (GADD45g) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL536Ra01 Recombinant Growth Arrest And DNA Damage Inducible Protein Gamma (GADD45g) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Gamma (GADD45g) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Gamma (GADD45g) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Growth Arrest And DNA Damage Inducible Protein Gamma (GADD45g) CLIA Kit Customized Service Offer
n/a ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Gamma (GADD45g) ELISA Kit Customized Service Offer
  1. "A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK."Cell 95:521-530(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Cytokine response gene 6 induces p21 and regulates both cell growth and arrest."Oncogene 18:6573-6582(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Assignment of human GADD45G to chromosome 9q22.1-->q22.3 by radiation hybrid mapping."Cytogenet. Cell Genet. 88:95-96(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle."J. Biol. Chem. 278:28079-28088(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Crystal structure of human Gadd45gamma reveals an active dimer."Protein Cell 2:814-826(2011) [PubMed] [Europe PMC] [Abstract]