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Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b)

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GADD45BETA; MYD118; Myeloid differentiation primary response protein MyD118; Negative growth regulatory protein MyD118

Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b)
CCC L535
HGNC 4096
MGI 107776
PubMed 19119186
RGD 1309080
UniProt O75293
Wiki GADD45B
GADD45b is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs.
Gadd45b is required for activity-induced DNA demethylation of specific promoters and expression of corresponding genes necessary for adult neurogenesis, including brain-derived neurotrophic factor and fibroblast growth factor. Hence GADD45B is implicated in affecting synaptic plasticity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL535Hu01 Recombinant Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL535Hu01 Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) WB; IHC
Assay Kits n/a CLIA Kit for Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Growth Arrest And DNA Damage Inducible Protein Beta (GADD45b) ELISA Kit Customized Service Offer
  1. "A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK."Cell 95:521-530(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Assignment of human GADD45G to chromosome 9q22.1-->q22.3 by radiation hybrid mapping."Cytogenet. Cell Genet. 88:95-96(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle."J. Biol. Chem. 278:28079-28088(2003) [PubMed] [Europe PMC] [Abstract]