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DIX Domain Containing Protein 1 (DIXDC1)

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CCD1; Dixin; Coiled-coil protein DIX1; DIX domain-containing protein 1

DIX Domain Containing Protein 1 (DIXDC1)
CCC L436
HGNC 23695
MGI 2679721
PubMed 22832659
RGD 1309902
UniProt Q155Q3
Wiki DIXDC1
The 3-prime UTR of the cDNA contains an Alu element, and the deduced protein contains 493 amino acids. RT-PCR ELISA detected high expression in adult whole brain and in several specific brain regions. Intermediate expression was detected in all other tissues and brain regions examined.
The deduced 472-amino acid DIXDC1 protein has a central myosin tail homology (MTH) region similar to those found in MYH1 and MYH2, as well as a C-terminal DIX domain. Within the MTH region, DIXDC1 contains 2 tyrosine phosphorylation sites and a leucine zipper motif. DIXDC1 was predicted to be a cytoplasmic protein.In contrast with human DIXDC1, the MTH region of mouse Dixdc1 has only 1 tyrosine phosphorylation site and no leucine zipper motif.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL436Hu01 Recombinant DIX Domain Containing Protein 1 (DIXDC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL436Hu01 Polyclonal Antibody to DIX Domain Containing Protein 1 (DIXDC1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for DIX Domain Containing Protein 1 (DIXDC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for DIX Domain Containing Protein 1 (DIXDC1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL436Mu01 Recombinant DIX Domain Containing Protein 1 (DIXDC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL436Mu01 Polyclonal Antibody to DIX Domain Containing Protein 1 (DIXDC1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for DIX Domain Containing Protein 1 (DIXDC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for DIX Domain Containing Protein 1 (DIXDC1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DIX Domain Containing Protein 1 (DIXDC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DIX Domain Containing Protein 1 (DIXDC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DIX Domain Containing Protein 1 (DIXDC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DIX Domain Containing Protein 1 (DIXDC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for DIX Domain Containing Protein 1 (DIXDC1) ELISA Kit Customized Service Offer
  1. "DIXDC1 isoform, l-DIXDC1, is a novel filamentous actin-binding protein."Biochem. Biophys. Res. Commun. 347:22-30(2006) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms."J. Biol. Chem. 279:39366-39373(2004) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "DIXDC1 co-localizes and interacts with gamma-tubulin in HEK293 cells."Cell Biol. Int. 33:697-701(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Wnt signaling stabilizes the DIXDC1 protein through decreased ubiquitin-dependent degradation."Cancer Sci. 101:700-706(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system."Proteomics 10:1780-1793(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Molecular basis of Wnt activation via the DIX-domain protein Ccd1."J. Biol. Chem. 286:8597-8608(2011) [PubMed] [Europe PMC] [Abstract]