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Sal Like Protein 4 (SALL4)

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ZNF797; Zinc finger protein 797; Zinc finger protein SALL4

Sal Like Protein 4 (SALL4)
CCC L024
HGNC 15924
MGI 2139360
PubMed 23758232
UniProt Q9UJQ4
Wiki SALL4
SALL4 gene encodes a protein with 3 C2H2 double zinc finger domains of the SAL-type, the second of which has a single C2H2 zinc finger attached at its C-terminal end, as well as an N-terminal C2HC zinc finger motif typical for vertebrate SAL-like proteins. By Northern blot analysis, they detected expression of a 5.5-kb SALL4 transcript exclusively in adult testis. RT-PCR confirmed expression in adult testis and revealed faint SALL4 expression in ovary and spleen.Northern blot analysis of adult mouse tissues detected a 5.0- to 5.5-kb transcript only in testis and ovary. In situ hybridization revealed widespread Sall4 expression in early mouse embryos. Expression was gradually confined to the head region and the primitive streak, and later there was prominent expression in the developing midbrain, branchial arches, limbs, and genital papilla.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL024Hu01 Recombinant Sal Like Protein 4 (SALL4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL024Hu01 Polyclonal Antibody to Sal Like Protein 4 (SALL4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Sal Like Protein 4 (SALL4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sal Like Protein 4 (SALL4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sal Like Protein 4 (SALL4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sal Like Protein 4 (SALL4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sal Like Protein 4 (SALL4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sal Like Protein 4 (SALL4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sal Like Protein 4 (SALL4) ELISA Kit Customized Service Offer
  1. "SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice."Blood 108:2726-2735(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Okihiro syndrome is caused by SALL4 mutations."Hum. Mol. Genet. 11:2979-2987(2002) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Sumoylation is important for stability, subcellular localization, and transcriptional activity of SALL4, an essential stem cell transcription factor."J. Biol. Chem. 287:38600-38608(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Duane radial ray syndrome (Okihiro syndrome) maps to 20q13 and results from mutations in SALL4, a new member of the SAL family."Am. J. Hum. Genet. 71:1195-1199(2002) [PubMed] [Europe PMC] [Abstract]
  9. "A SALL4 zinc finger missense mutation predicted to result in increased DNA binding affinity is associated with cranial midline defects and mild features of Okihiro syndrome."Hum. Genet. 119:154-161(2006) [PubMed] [Europe PMC] [Abstract]
  10. "IVIC syndrome is caused by a c.2607delA mutation in the SALL4 locus."Am. J. Med. Genet. A 143:326-332(2007) [PubMed] [Europe PMC] [Abstract]